Publications by authors named "Mikhail E Blokhin"
Curr Issues Mol Biol
March 2023
Article Synopsis
- - Metabolic syndrome involves issues with glucose and lipid metabolism, requiring effective medication for treatment.
- - Researchers created potential drugs that activate nuclear receptors PPAR-alpha and gamma to improve metabolism, utilizing a specific chemical structure derived from glitazars.
- - In studies with obese mice suffering from type 2 diabetes, one drug effectively lowered triglycerides and blood sugar, while proving safe for the liver.
Article Synopsis
- Despite a decrease in SARS-CoV-2 cases and deaths, the need for effective antiviral drug development against future viruses is still critical.
- Researchers investigated the potential of triterpenic acid amides to inhibit the main protease of SARS-CoV-2, employing molecular modeling techniques.
- FRET-based enzyme assays demonstrated that these compounds can significantly inhibit the protease at micromolar levels.
