Publications by authors named "Mikhail A Sevostyanov"

With the help of laser ablation, a technology for obtaining nanosized crystalline selenium particles (SeNPs) has been created. The SeNPs do not exhibit significant toxic properties, in contrast to molecular selenium compounds. The administration of SeNPs can significantly increase the viabilities of SH-SY5Y and PCMF cells after radiation exposure.

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The article is devoted to the study of melted ingots, plates rolled from them, and the resulting spherical powder made of corrosion-resistant 316L steel with the addition of 0.2 wt.% and 0.

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Foodborne infections are an important global health problem due to their high prevalence and potential for severe complications. Bacterial contamination of meat during processing at the enterprise can be a source of foodborne infections. Polymeric coatings with antibacterial properties can be applied to prevent bacterial contamination.

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An electrospark technology has been developed for obtaining a colloidal solution containing nanosized amorphous carbon. The advantages of the technology are its low cost and high performance. The colloidal solution of nanosized carbon is highly stable.

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Using the methods of electric arc melting, intermediate heat treatments, and consecutive intensive plastic deformation, a Ti-Nb-Zr alloy wire with a diameter of 1200 μm was obtained with a homogeneous chemical and phase (β-Ti body-centered crystal lattice) composition corresponding to the presence of superelasticity and shape memory effect, corrosion resistance and biocompatibility. Perhaps the wire structure is represented by grains with a nanoscale diameter. For the wire obtained after stabilizing annealing, the proof strength Rp0.

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Article Synopsis
  • The study focuses on developing biodegradable polymer coatings for stents using poly(lactic-co-glycolic acid) (PLGA), which can release large molecules like prourokinase over time.
  • The coatings exhibit significant elasticity and tensile strength, degrade slowly in isotonic solutions (0.05%-1.0% per day), and maintain around 90% enzymatic activity of prourokinase during release.
  • Testing in animals showed no short-term toxicity or complications post-surgery, with minimal traces of PLGA found after 60 days, indicating the coatings are safe and effective for medical use.
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The novelty of the study is the development, creation, and investigation of biodegradable polymeric membranes based on polylactide, that are capable of directed release of large molecular weight biomolecules, particularly, prourokinase protein (MW = 46 kDa). Prourokinase is a medication with significant thrombolytic activity. The created membranes possess the required mechanical properties (relative extension value from 2% to 10%, tensile strength from 40 to 85 MPa).

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The corrosion resistance of nanostructured nitinol (NiTi) was investigated using long-term tests in solutions simulating physiological fluids at static conditions, reflecting the material structure and metal concentration in the solutions. Mechanical polishing reduced the ion release by a factor of two to three, whereas annealing deteriorated the corrosion resistance. The depassivation and repassivation of nitinol surfaces were considered.

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This Article covers the influence of the concentration of gold nanoparticles on laser-induced water decomposition. It was established that addition of gold nanoparticles intensifies laser-induced water decomposition by almost 2 orders of magnitude. The water decomposition rate was shown to be maximal at a nanoparticle concentration around 10 NP/mL, whereas a decrease or increase of nanoparticle concentration leads to a decrease of water decomposition rate.

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Unmodified hydrated С fullerene molecules (CUHFM) were shown to reduce the formation ROS in water and 8-oxoguanine in DNA upon ionizing radiation impact. CUHFM efficiently eliminate long-lived protein radicals arising after irradiation. In irradiated mice CUHFM reduce the rate of single/double-strand DNA breaks and amount of chromosomal breaks.

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Article Synopsis
  • A new technology has been developed to create nitinol materials with titanium- or tantalum-enriched surface layers, which reduce reactive oxygen species and protein radicals.
  • These enriched materials showed nearly double the cell growth in human myofibroblasts and mesenchymal stromal cells compared to untreated nitinol.
  • The formation of fibrous capsules around the implants indicates that titanium- or tantalum-coated nitinol is more biocompatible and less reactive than pure nitinol, making it promising for medical use.
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