Effect of locally excited state on fluorescence transition dipole moment in quadrupolar molecules subjected to symmetry breaking charge transfer.

In excited centrosymmetric donor-acceptor triads of type A-D-A or D-A-D, symmetry breaking charge transfer (SBCT) in polar media has been explored for a few decades. SBCT is accompanied by significant reorganization of the electronic structure of the molecule, which leads to a change in the fluorescence transition dipole moment (TDM). Previously, experiments revealed a 20%-30% reduction in TDM, which occurs on the timescale of SBCT.

Apoptotic Receptors and CD107a Expression by NK Cells in an Interaction Model with Trophoblast Cells.

Natural killer cells (NK cells) exert cytotoxicity towards target cells in several ways, including the expression of apoptosis-mediating ligands (TRAIL, FasL). In addition, NK cells themselves may be susceptible to apoptosis due to the expression of TRAIL receptors. These receptors include TRAIL-R1 (DR4), TRAIL-R2 (DR5), capable of inducing apoptosis, and TRAIL-R3 (DcR1), TRAIL-R4 (DcR2), the so-called "decoy receptors", which lack an intracellular domain initiating activation of caspases.

Treatment of atopic dermatitis with upadacitinib: adcare single center experience.

Introduction: The role of upadacitinib in the management of moderate to severe atopic dermatitis seems promising, but more data on its efficacy and safety are needed. This study endeavors to assess the practical impact and safety of upadacitinib in patients with moderate to severe atopic dermatitis. The study aims to evaluate the efficacy and safety of upadacitinib in the treatment of moderate to severe atopic dermatitis, focusing on analyzing patient responses to the treatment.

[The interdisciplinary approach as tool of pharmaceutical education of children: from theory to practice].

The pharmaceutical literacy is a necessary element of ensuring quality of human life that is to be formed at early age. The article demonstrates that key direction of development of health literacy is pharmaceutical education involving pharmaceutical workers. The necessity of development of pharmaceutical literacy in children through involvement into process of pharmaceutical education pedagogues and parents/legal representatives of child.

[Effects of oxytocin pathway gene polymorphisms and adverse childhood experiences on emotion recognition in schizophrenia spectrum disorders].

Objective: To study a role of the interaction of oxytocin pathway gene polymorphisms and adverse childhood experiences (ACE) in facial emotion recognition (FER) deficits in schizophrenia.

Material And Methods: Patients with schizophrenia spectrum disorders (699) completed cognitive testing, which included a FER task. We determined patients' genotypes for common polymorphisms in three of the oxytocin pathway genes which were previously associated with face perception: (rs53576, rs7632287), (rs3796863) and (rs4778599).

Natural Killer Cell Derived Microvesicles Affect the Function of Trophoblast Cells.

The interaction of natural killer (NK) and trophoblast cells underlies the formation of immune tolerance in the mother-fetus system and the maintenance of the physiological course of pregnancy. In addition, NK cells affect the function of trophoblast cells, interacting with them via the receptor apparatus and through the production of cytokines. Microvesicles (MVs) derived from NK cells are able to change the function of target cells.

Digital media in intergenerational communication: Status quo and future scenarios for the grandparent-grandchild relationship.

Communication technologies play an important role in maintaining the grandparent-grandchild (GP-GC) relationship. Based on Media Richness Theory, this study investigates the frequency of use (RQ1) and perceived quality (RQ2) of established media as well as the potential use of selected innovative media (RQ3) in GP-GC relationships with a particular focus on digital media. A cross-sectional online survey and vignette experiment were conducted in February 2021 among  = 286 university students in Germany (mean age 23 years, 57% female) who reported on the direct and mediated communication with their grandparents.

A study of the association between polymorphisms in the genes for interleukins IL-6 and IL-10 and negative symptoms subdomains in schizophrenia.

Background: Schizophrenia is a severe mental illness manifested by various symptoms. Negative symptoms (NS) are associated with disability and poor function of patients. The study of NS neurobiology is complicated by their heterogeneity.

SGLT2 Inhibitor Empagliflozin Modulates Ion Channels in Adult Zebrafish Heart.

Empagliflozin, an inhibitor of sodium-glucose co-transporter 2 (iSGLT2), improves cardiovascular outcomes in patients with and without diabetes and possesses an antiarrhythmic activity. However, the mechanisms of these protective effects have not been fully elucidated. This study aimed to explore the impact of empagliflozin on ion channel activity and electrophysiological characteristics in the ventricular myocardium.

Comparative analysis of classification algorithms on the breast cancer recurrence using machine learning.

This paper presents a comparative evaluation of classification algorithms using Waikato Environment for Knowledge Analysis (WEKA) software. The main goal of the paper is to conduct a comprehensive comparison and determine which predictive modelling technique is best for the problem of classifying breast cancer recurrence. The dataset for this study consists of 286 instances (201 instances belong to recurrence class and 85 instances belong to non-recurrence class) and 10 attributes.

How Customers Evaluate Genitalia versus Torso Sex Toys on Amazon.com: A Content Analysis of Product Reviews.

Sex toys are widely marketed on the Internet. Browsing for, buying, and reviewing sex toys online are popular cybersexual activities. The aim of this study was to investigate consumers' experiences with different types of realistic sex toys via online product reviews on Amazon.

Case Report: Loss-of-Function Genetic Variant Associated With Ventricular Fibrillation.

Genetic variants in the gene, encoding the SUR2 auxiliary subunit from K channels, were previously linked with various inherited diseases. This wide range of congenital disorders includes multisystem and cardiovascular pathologies. The gain-of-function mutations result in Cantu syndrome, acromegaloid facial appearance, hypertrichosis, and acromegaloid facial features.

The Role of Cytokines in Maintaining the Dynamics of Cell-Cell Interaction between Natural Killer Cells and Trophoblast Cells.

We analyzed the effect of individual cytokines that are secretory products of placenta typical of the uteroplacental bed. The proinflammatory cytokines IL-6, IFNγ, and IL-1β increased the expression of TGFβR2 molecule by trophoblast cells, while VEGF and PLGF increased the expression of CD45, CD29, and CD54 adhesion molecule by trophoblast cells. The antiinflammatory cytokine IL-4 increased LeptinR expression by trophoblast cells.

Corrigendum: Sexual Interaction in Digital Contexts and Its Implications for Sexual Health: A Conceptual Analysis.

[This corrects the article DOI: 10.3389/fpsyg.2021.

T-Lymphocyte proliferative activity in early pregnancy and outside pregnancy state.

T-lymphocytes are present in the endometrium before pregnancy and their number varies depending on menstrual cycle stage. Despite T-lymphocyte population heterogeneity, there is no clear vision of general mechanisms of decidua T-lymphocyte pool formation. One of the assumed variants is T-lymphocyte proliferation .

Sexual Interaction in Digital Contexts and Its Implications for Sexual Health: A Conceptual Analysis.

Based on its prevalence, there is an urgent need to better understand the mechanisms, opportunities and risks of (SIDC) that are related with sexual arousal. While there is a growing body of literature on SIDC, there is also a lack of conceptual clarity and classification. Therefore, based on a conceptual analysis, we propose to distinguish between sexual interaction (1) , (2) , and (3) digital technologies.

[Associations between the oxytocinergic system genes, perinatal complications and interpersonal relationships in patients with schizophrenia].

Objective: To search for the associations between genes of the oxytocinergic pathway and psychosocial functioning in schizophrenia, namely, the ability of schizophrenic patients to form interpersonal relationships, taking into account the influence of such an environmental factor as perinatal complications.

Material And Methods: The study included 383 people (140 women and 243 men, mean age 32.6±11.

Functional Analysis of SCN5A Genetic Variants Associated with Brugada Syndrome.

Background: Brugada syndrome (BrS) is a rare inherited cardiac arrhythmia with increased risk of sudden cardiac death. Mutations in gene SCN5A, which encodes the α-subunit of cardiac voltage-gated sodium channel NaV1.5, have been identified in over 20% of patients with BrS.

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells.

NK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line.

The uteroplacental contact zone cytokine influence on NK cell cytotoxicity to trophoblasts.

Objective: The present study was to estimate the role of cytokines for trophoblast death in NK cells presence.

Methods: This study involves assessment of NK-92 line NK cell cytotoxic activity against JEG-3 line cells, in presence of cytokines. We also assessed the effect of secretory placenta products on NK cell cytotoxic activity toward JEG-3 line cells.

Methodological Approaches to Assessing the Size and Morphology of Microvesicles of Cell Lines.

Morphological properties and the size of microvesicles were assessed using atomic force microscopy, electron microscopy, and granulometric analysis. As these methods require significant numbers of microvesicles, we chose microvesicles derived from cell lines for our research.