Cardio-ankle vascular index for predicting cardiovascular morbimortality and determinants for its progression in the prospective advanced approach to arterial stiffness (TRIPLE-A-Stiffness) study.

Background: The cardio-ankle vascular index (CAVI) measure of arterial stiffness is associated with prevalent cardiovascular risk factors, while its predictive value for cardiovascular events remains to be established. The aim was to determine associations of CAVI with cardiovascular morbimortality (primary outcome) and all-cause mortality (secondary outcome), and to establish the determinants of CAVI progression.

Methods: TRIPLE-A-Stiffness, an international multicentre prospective longitudinal study, enrolled >2000 subjects ≥40 years old at 32 centres from 18 European countries.

[Obstructive sleep apnea syndrome and cardiovascular risk factors in the antihypertensive therapy "escape" phenomenon].

Aim: To assess the role of obstructive sleep apnea and other cardiovascular (CV) risk factors in the development of the antihypertensive therapy (AHT) efficacy "escape" phenomenon in patients with arterial hypertension (AH).

Materials And Methods: The data of 75 patients with AH stage I-II, grades 1-3 were proceeded. All patients included in the study underwent night respiratory monitoring.

[Modern determinants of intergenerational relationships.].

The article deals with intergenerational relationships and mutual assessments, gives an idea of the values of young people and the elderly, obtained on the basis of interviews. The authors come to the conclusion about the natural variability of intergenerational relationships, which due to adaptive capabilities, do not lead to real conflict between the studied age groups.

[Adherence and efficacy of long-term PAP therapy in patients with sleep-related breathing disorders associated with cardiac conduction disorders].

Aim: To study the effectiveness of prolonged use of PAP therapy (positive airway pressure therapy) in eliminating sleep respiratory disorders and associated cardiac conduction disturbances.

Materials And Methods: We included 21 patients who were examined at the Myasnikov Institute of Clinical Cardiology, National Medical Research Center of Cardiology, regarding cardiac rhythm and conduction disturbances, as well as obstructive sleep apnea and who have been on PAP therapy for more than 12 months. The average age was 66.

Towards realization of longer life.

The current demographic situation in the world is characterized by an increase in average life expectancy, low birth rate, as well as an increase in the number of older and senior people, which is why our epoch is referred to as «the age of ageing». [..

Sporadic increases of radioactive aerosols as a possible reason for heavy nuclides enhancements recorded with the en-detectors.

Some unexpected sporadic increases of an environmental radioactive background have been recorded at mountain level at Baksan Neutrino Observatory (BNO, 1700 m above sea level) using electron-neutron detectors (en-detectors), which could be explained by radioactive aerosol enhancements. The large area inorganic scintillator en-detectors developed for cosmic ray study are continuously monitoring environmental thermal neutron fluxes at various geophysical conditions. Application of the pulse shape discrimination method allows us to select and separately measure both thermal neutrons and radioactive beta-decay nuclides being products of radon decays in air (mostly Rn-222 and Rn-220).

[Clinical profile of patients with obstructive sleep apnea syndrome in a cardiology hospital].

Relevance: Obstructive sleep apnea syndrome (OSAS) is an important medical and social problem due to its high prevalence and impact on quality of life. The relationship between OSAS and cardiovascular pathology has been proven by many studies, which confirms the necessity for early diagnosis of OSAS and its treatment for the prevention of fatal and non-fatal events.

Aim: to study epidemiological and clinical profile of the patients referred by a cardiologist to a specialized sleep laboratory to verify the diagnosis of OSAS.

[Influence of modifiable cardiovascular risk factors on antihypertensive therapy efficiency escape].

Aim: To evaluate the influence of cardiovascular risk factors on antihypertensive therapy (AHT) efficiency escape (EE).

Subjects And Methods: Data on 59 patients with grades 1-3 hypertension (Stages I-II) were analyzed. During chosen AHT, 24-hour blood pressure monitoring was done at baseline, 1 and 3 months after beginning the observation to identify/rule out the AHT EE phenomenon.

[Risk-oriented model of the control of the level of electric magnetic fields of base stations of cellular communications].

The purpose of this study was to give the description of harmful effects of the impact of electromagnetic radiations from base stations of cellular communication as the most common sources of radio frequencies of electromagnetic fields in the environment. The highest values of the energy flux density were measured on the roofs of houses where antennas are installed - more than 10 pW/cm. The lowest values were recorded in inside premises with expositions of 0.

[International cooperation on aging: areas and players].

This review article is devoted to the issues of international cooperation on ageing. It aims at describing the basic areas of cooperation and introducing its major players. Within the limited length of a journal article it is hardly possible to offer an exhaustive presentation of all available information; thus the article strives to provide a general orientation within the selected themes.

Development of mass spectrometry selected reaction monitoring method for quantitation and pharmacokinetic study of stepharine in rabbit plasma.

Highly sensitive liquid chromatography mass spectrometry method on triple quadrupole (QQQ) mass spectrometer was successfully applied for pharmacokinetic study of stepharine in rabbit plasma. Specific ion transitions of stepharine protonated precursor ion were selected and recorded in the certain retention time employing dynamic selected reaction monitoring mode. The developed method facilitated quantitative measurements of stepharine in plasma samples in linear range of five orders of magnitude with high accuracy and low standard deviation coefficient and pharmacokinetics parameters were calculated.

[About the prevalence of diseases of pancreas in the Udmurt Republic].

Unlabelled: THE AIM OF OUR INVESTIGATION: To study the dynamic of morbidity level of pancreas in Udmurt Republic (UR) and to prognose it for nearest years.

Materials And Methods: We used the official statistic materials of Republic medical information-analytic center for 2001-2011 yy. In analyses of received data we used trend models and statistic method.

[Saint Petersburg Institute of Bioregulation and Gerontology: achievements and prospects (towards the 20th anniversary)].

The article presents the results of the 20-years' long activity of the Saint Petersburg Institute of Bioregulation and Gerontology founded to fulfill the basic and applied tasks in the sphere of gerontology and to integrate with medical practice new methods for preventing premature aging and age-related pathology by means of pharmaceuticals based on peptide bioregulators. Among the Institute main achievements are the scientific developments in the field of peptide regulation of aging, creation of a new medical domain--bioregulation therapy, and foundation of the Russian school of biogerontology. As a result of investigations, a key role of peptides in the regulation of aging process has been established, and a method of bioregulators complex application has been developed to increase organism resistance to various unfavorable factors and enhancement of human vital resource.

[Implementation of the Madrid International Plan of Action on Aging in the CIS countries: the first 10 years].

In this article the information on policy action on aging in the CIS countries and Georgia (CIS+) are presented and discussed. The process of implementation of the Madrid International Plan of Action on Aging (MIPAA) from 2002 through 2012 is chosen as a framework for analyzing the government policy on ageing. The article begins with a concise overview of the demographic situation in the CIS+ countries, which belong to various stages of demographic transition.

Biogerontology in Russia: from past to future.

The paper presents major steps of gerontology development in Russia. The issues of training in gerontology and geriatrics, institutional infrastructure within the Gerontological Society of the Russian Academy of Sciences and its activities have been considered therein. Some results of Russian researchers obtained during 2005-2010 have been summarized as well.

[Remote results of using prostaglandins E1 and immunotherapy in combined modality treatment of various-aetiology trophic ulcers].

The purpose of this study was to assess short- and long-term efficacy of combined-modality therapy (comprising PGE1-group preparations and immunocorrection) used to treat indolent trophic ulcers in patients presenting with chronic venous insufficiency (CVI) and cutaneous angiitis. Examined herein were both immediate and remote therapeutic outcomes obtained in patients suffering from indolent trophic ulcers secondary to CVI (post-thrombophlebic disease [PTPD] and varicose disease [VD]), as well as ulcers resulting from vasculitis or vasculopathy. The conventional therapy was supplemented with infusion of PGE1-group preparations and immunocorrection.

[The 15th anniversary of the Gerontological Society of The Russian Academy of Sciences].

The article highlights main activities and results as well as major trends of developments and undertakings of the Gerontological Society of the Russian Academy of Sciences founded in March 1994.

[Characteristic of biological properties of Neisseria gonorrhoeae and parameters of local immunity during urogenital gonococcal infection].

Aim: To study the prevalence and expression of antilactoferrin, IgA- and slgA-protease activity of gonococci and state of local immunity during various forms of urogenital gonorrhea.

Materials And Methods: Ability to inactivate lactoferrin (ALfA), IgA and secretory IgA (slgA) was studied in 28 Neisseria gonorrhoeae strains isolated from patients with localized gonorrhea and 26 strains isolated from patients with systemic signs of gonorrhea. State of the local immunity was assessed on the lactoferrin, IgA and slgA levels, which were measured by immunofluorescence assay in ejaculate of 54 patients with gonorrhea and 18 healthy males.

[10th anniversary of the Year of Old Person: towards the society for all ages].

The paper highlights the milestones in the development of the UN idea of the Society for All Ages, originally announced as a motto of the International Year of Old Persons and later accepted as a central concept of the Madrid International Plan of Action on Aging (MIPA). In accord with MIPA building of the Society for All Ages will be a major issue in policies and programmes on aging in the XXI century. According to the UN experts opinion demographic tendencies may produce considerable impact on economy, social sphere and safety of Russia.

[Life expectancy at older ages and alternative approach to aging measurement (the case of St. Petersburg)].

St. Petersburg Institute of Bioregulation and Gerontology, NWB of RAMS, 3 pr. Dinamo, St.

Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia.

We estimated the frequency of CYP1A1, CYP1A2, CYP1B1, CYP19, and SULT1A1 allelic variants in a female population of the Novosibirsk district and their association with the elevated risk of breast (BC), ovarian (OC), and endometrial (EC) cancers. Significant differences (OR = 2.34, p = 0.

[Mini-laparoscopic fundoplication by Nissen in the treatment of gastroesophageal reflux at children].

Results of surgical treatment of 180 children with gastroesophageal reflux are analyzed. Laparoscopic fundoplication by Nissen was used. Positive result was achieved in all the cases, there were no lethal outcomes.

[Administration of prostaglandins Ei and immunotherapy in management of various-genesis trophic ulcers].

Objective: To study the dynamics of the indices of microcirculation and the immune status in patients suffering from indolent trophic ulcers with the preserved arterial blood flow, as well as a possibility of treating them by means of PGEi-group preparations combined with immunocorrection.

Patients And Methods: From 2002 to 2006 in the Clinic of Vascular Surgery of Municipal Clinical Hospital No 3 of the city of Chelyabinsk, we examined a total of 158 patients suffering from indolent trophic ulcers of the lower extremities with the preserved arterial blood flow (venous ulcers and cutaneous angiitis). Also studied were the immune status and tissue perfusion indices, cytology of the ulcers' surface.

Enhancer elements in the mouse CYP1A2 gene: a comparative sequencing among different inbred mouse strains.

CYP1A2 expression is constitutively high in mouse liver and is well known for metabolizing several drugs and many procarcinogens to reactive intermediates that can cause toxicity or cancer. In the present study, the basal level of hepatic CYP1A2 activity was shown to vary among different inbred mouse strains. The highest methoxyresorufin-O-demethylase activity (261+/-52pmol/mgprotein/min) was registered in CC57BR and the lowest (82+/-11pmol/mgprotein/min) in C3H/a.