Publications by authors named "Mikel Rezola Artero"
Key Points: We evidenced terminal pathway activation (C5b-9 deposits) in most of the glomeruli on kidney biopsy of C3 glomerulopathy. The amount of C5b-9 deposits correlated with disease prognosis in C3 glomerulopathy. Increased terminal pathway activation was found predominantly in a subgroup exhibiting an immuno-fibroblastic signature.
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- Complement system overactivation is crucial in lupus nephritis (LN), and this study focuses on anti-C3 autoantibodies as potential biomarkers for disease activity, comparing them with anti-C4 autoantibodies.
- The analysis involved 85 LN patients over 8 years, examining the presence of these autoantibodies and their correlation with clinical parameters and disease progression.
- Results showed that anti-C3 IgG had stronger clinical correlations and predictive value for disease exacerbation than anti-C4, suggesting that monitoring anti-C3 alongside anti-dsDNA could enhance LN management.
Despite the progress of anti-cancer treatment, the prognosis of many patients with solid tumors is still dismal. Reliable noninvasive biomarkers are needed to predict patient survival and therapy response. Here, we propose a approach: a work-up of assays to comprehensively evaluate complement proteins, activation fragments, and autoantibodies targeting complement proteins in plasma, which we correlated with the intratumoral complement activation, and/or local production, focusing on localized and metastatic clear cell renal cell carcinoma (ccRCC).
View Article and Find Full Text PDFIntroduction: The complement system is involved in numerous diseases, through diverse mechanisms and degree of activation. With the emergence of complement targeting therapeutic, simple and accessible tools to evaluate the extent of complement activation are strongly needed.
Methods: We evaluated two multiplex panels, measuring complement activation fragments (C4a, C3a, C5a, Bb, Ba, sC5b9) and intact components or regulators (C1q, C2, C3, C4, C5, FD, FP, FH, FI).