A cost-utility analysis of clopidogrel in patients with ST elevation acute coronary syndromes in the UK.

Objective: To assess the long-term cost effectiveness of treatment for 1 month, and for 1 year with clopidogrel in addition to standard therapy (including aspirin) compared with standard therapy alone, in patients diagnosed with ST elevation acute myocardial infarction (STEMI) in the UK.

Design: Cost utility analysis using a cohort Markov model, incorporating clinical data from two pivotal clinical trials (the COMMIT/CCS-2 and CLARITY-TIMI 28 trials) and data from UK and non-UK observational studies.

Setting: Health economic evaluation carried out from the perspective of the UK NHS.

Pulsatile machine perfusion vs. cold storage of kidneys for transplantation: a rapid and systematic review.

Objective: To identify and prioritize key areas for further research in kidney preservation systems.

Materials And Methods: We conducted a systematic review and meta-analysis of the effectiveness of machine perfusion and cold storage techniques in reducing delayed graft function (DGF) and improving graft survival in recipients of kidneys from beating and non-heart-beating donors. Literature quantifying the link between DGF and graft survival was used to evaluate the potential long-term impact of machine perfusion and cold storage systems.