Publications by authors named "Mike R Jirousek"
Bioorg Med Chem Lett
June 2003
Article Synopsis
- A novel series of oxalyl-aryl-amino benzoic acid-based inhibitors for PTP1B was developed.
- Using a solution phase parallel synthesis method, researchers quickly identified a potent inhibitor with a dissociation constant (K(i)) of 76 nM.
- The inhibitor showed moderate selectivity for PTP1B over TCPTP, acting by binding to a secondary phosphotyrosine site near the catalytic site.
