Head-to-Head Comparison of Soluble vs. Qβ VLP Circumsporozoite Protein Vaccines Reveals Selective Enhancement of NANP Repeat Responses.

Circumsporozoite protein (CSP) of Plasmodium falciparum is a promising malaria vaccine target. RTS,S, the most advanced malaria vaccine candidate consists of the central NANP repeat and carboxy-terminal region of CSP displayed on a hepatitis B virus-like particle (VLP). To build upon the success of RTS,S, we produced a near full-length Plasmodium falciparum CSP that also includes the conserved amino-terminal region of CSP.

Living and dying with severe chronic obstructive pulmonary disease: multi-perspective longitudinal qualitative study.

Objectives: To understand the perspectives of people with severe chronic obstructive pulmonary disease (COPD) as their illness progresses, and of their informal and professional carers, to inform provision of care for people living and dying with COPD.

Design: Up to four serial qualitative interviews were conducted with each patient and nominated carer over 18 months. Interviews were transcribed and analysed both thematically and as narratives.

Living and dying with severe chronic obstructive pulmonary disease: multi-perspective longitudinal qualitative study.

Objectives: To understand the perspectives of people with severe chronic obstructive pulmonary disease (COPD) as their illness progresses, and of their informal and professional carers, to inform provision of care for people living and dying with COPD.

Design: Up to four serial qualitative interviews were conducted with each patient and nominated carer over 18 months. Interviews were transcribed and analysed both thematically and as narratives.

The impact of general practitioner morale on patient satisfaction with care: a cross-sectional study.

Background: The association between stress and morale among general practitioners (GP) is well documented. However, the impact of GP stress or low morale on patient care is less clear. GPs in the UK now routinely survey patients about the quality of their care including organizational issues and consultation skills and the General Practice Assessment Questionnaire (GPAQ) is widely used for this purpose.

The experience of caring for someone over 75 years of age: results from a Scottish General Practice population.

Aims And Objectives: To understand the unpaid carers' experiences of looking after someone aged over 75 at all stages of their caring career.

Background: The role of, and support for, unpaid carers have become central in the debates surrounding community care in the UK. This paper presents the findings of a study to elicit the complexities of the caring role and inform the Primary Health Care Team to help support carers more effectively.

Morale among general practitioners: qualitative study exploring relations between partnership arrangements, personal style, and workload.

Objectives: To explore general practitioners' experiences of wellbeing and distress at work, to identify their perceptions of the causes of and solutions to distress, and to draw out implications for improving morale in general practice.

Design: Three stage qualitative study consisting of one to one unstructured interviews, one to one guided interviews, and focus groups.

Setting: Fife, Lothian, and the Borders, South East Scotland.