A pragmatic randomised controlled trial in primary care of the Camden Weight Loss (CAMWEL) programme.

Objectives: To evaluate effectiveness of a structured one-to-one behaviour change programme on weight loss in obese and overweight individuals.

Design: Randomised controlled trial.

Setting: 23 general practices in Camden, London.

Relationship of maternal weight status and weight gain rate during pregnancy to the development of advanced beta cell autoimmunity in the offspring: a prospective birth cohort study.

Objective: This study set out to examine how maternal initial body mass index (BMI) and weight gain during pregnancy associate with advanced beta cell autoimmunity in the offspring.

Subjects: A population-based birth cohort of 4093 children with increased human leukocyte antigen (HLA)-conferred susceptibility to type 1 diabetes (T1D) and their mothers were recruited between 1997 and 2002 in two university hospital regions in Finland.

Methods: The children were monitored for T1D-associated autoantibodies at 3- to 12-month intervals.

Missing data: discussion points from the PSI missing data expert group.

The Points to Consider Document on Missing Data was adopted by the Committee of Health and Medicinal Products (CHMP) in December 2001. In September 2007 the CHMP issued a recommendation to review the document, with particular emphasis on summarizing and critically appraising the pattern of drop-outs, explaining the role and limitations of the 'last observation carried forward' method and describing the CHMP's cautionary stance on the use of mixed models. In preparation for the release of the updated guidance document, statisticians in the Pharmaceutical Industry held a one-day expert group meeting in September 2008.

Unhealthy dietary patterns are associated with weight gain during pregnancy among Finnish women.

Objective: To study whether the dietary patterns of Finnish pregnant women are associated with their weight gain rate during pregnancy.

Design: A validated 181-item FFQ was applied retrospectively to assess the diet during the eighth month of pregnancy, and maternal height and maternal weight at first and last antenatal visits were recalled. Information on sociodemographic characteristics, parity and smoking of the pregnant women was obtained by a structured questionnaire and from the Finnish Birth Registry.

Sociodemographic and lifestyle characteristics are associated with antioxidant intake and the consumption of their dietary sources during pregnancy.

Objective: To analyse the associations of selected sociodemographic and lifestyle factors with the intake of antioxidant nutrients and consumption of their main dietary sources among pregnant women.

Design: A population-based cohort study. Dietary intake during pregnancy was assessed by a self-administered FFQ one to three months after the delivery.

Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child.

Background: Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes.

Long-term effects of reproductive history on all-cause mortality among adults in rural Bangladesh.

A woman's risk of dying is altered during pregnancy and immediately postpartum. Moreover, physiological and social changes associated with pregnancy may have long-term effects on mortality. Comparing these long-term associations among women and their husbands may provide insights into the nature of such a relationship.