Publications by authors named "Mike H R White"
Dis Model Mech
November 2020
Article Synopsis
- Inflammatory bowel diseases (IBDs) have serious health implications, with altered NF-κB signaling linked to their onset, prompting researchers to explore drug repositioning to target this pathway.
- The SysmedIBD Consortium developed a new pipeline to identify existing drugs that affect NF-κB signaling and tested them in animal models, finding that clarithromycin, a macrolide antibiotic, ranked highest for its anti-inflammatory potential.
- Experimental results showed clarithromycin's ability to modulate NF-κB activity and reduce colitis severity, suggesting it could be a promising candidate for further clinical trials in IBD treatment.
