Phantom evaluation of feasibility and applicability of artificial intelligence based pulmonary nodule detection in chest radiographs.

The aim of our study was to evaluate the specific performance of an artificial intelligence (AI) algorithm for lung nodule detection in chest radiography for a larger number of nodules of different sizes and densities using a standardized phantom approach. A total of 450 nodules with varying density (d1 to d3) and size (3, 5, 8, 10 and 12 mm) were inserted in a Lungman phantom at various locations. Radiographic images with varying projections were acquired and processed using the AI algorithm for nodule detection.

Cost-effectiveness of voretigene neparvovec in the treatment of patients with inherited retinal disease with RPE65 mutation in Switzerland.

Objective: We aimed to evaluate the cost-effectiveness of voretigene neparvovec (VN) compared with standard of care (SoC) for patients with inherited retinal disease (IRD) caused by a biallelic RPE65-mutation. VN is a live, non-replicating adeno-associated virus serotype 2 (AAV2). SoC is best supportive care provided to patients with visual impairment.