Publications by authors named "Mike Chong"
Article Synopsis
- - The study analyzed data from 703,901 individuals and identified 99 genetic loci related to physical activity levels and sedentary behavior, particularly focusing on leisure time activities and screen use.
- - Certain genes linked to sedentary behavior show heightened expression in skeletal muscle when influenced by resistance training, highlighting a connection between genetics and exercise.
- - The findings suggest that lower screen time and increased physical activity can positively impact health, but these effects may be influenced by factors like body mass index (BMI).
To develop an understanding of how images and symbols on student-designed orientation t-shirts represent students' beliefs about pharmacists' roles in practice. An exploratory qualitative study underpinned by perspectives on hidden curriculum and discursive practices was conducted at one Canadian pharmacy school. First-year students wrote responses to prompts about the t-shirts at the start and end of the school year.
View Article and Find Full Text PDFBackground: Hearing impairment (HI) genes are poorly studied in African populations.
Methods: We used whole exome sequencing (WES) to investigate pathogenic and likely pathogenic (PLP) variants in 10 individuals with HI, from four multiplex families from Cameroon, two of which were previously unresolved with a targeted gene enrichment (TGE) panel of 116 genes. In silico protein modelling, western blotting and live imaging of transfected HEK293 cells were performed to study protein structure and functions.
Background And Purpose: An important minority of cerebral small vessel disease (cSVD) is monogenic. Many monogenic cSVD genes are recognized to be associated with extracerebral phenotypes. We assessed the frequency of these phenotypes in existing literature.
View Article and Find Full Text PDFObjective: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD.
Methods: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (, , , , , and ) with intracerebral hemorrhage (ICH) (deep, lobar, all; 1,878 cases, 2,830 controls) and ischemic stroke (IS) (lacunar, cardioembolic, large vessel disease, all; 19,569 cases, 37,853 controls). We applied data quality filters and set statistical significance thresholds accounting for linkage disequilibrium and multiple testing.