Publications by authors named "Mike Bone"
Objective: Relaxation and imagery techniques have been widely used among patients with chronic physical illnesses other than end stage renal failure (ESRF). Case studies and some controlled studies suggest that relaxation and imagery techniques can be successfully used with hemodialysis patients to improve their adjustment. Nonetheless, randomized controlled studies are needed to systematically examine this effect.
View Article and Find Full Text PDF[The development of the life evaluation questionnaire for hemodialysis patients].
Turk Psikiyatri Derg
October 2009
Article Synopsis
- Current quality of life measures for end-stage renal failure (ESRF) do not account for patients' personal perspectives on evaluating their lives, which previous qualitative research has highlighted as crucial for clinical practice.
- Three studies were conducted to quantify and validate a new questionnaire that captures these personal evaluations of life among hemodialysis patients, focusing on aspects like limitations and feelings towards caregivers.
- The results support the questionnaire's reliability and validity, indicating it can effectively complement existing quality of life measures tailored for patients undergoing hemodialysis.
Article Synopsis
- The study emphasizes the importance of understanding the experiences of end-stage renal failure (ESRF) beyond just functional impairment and emotional distress, highlighting the need for qualitative research from patients' perspectives.
- Interviews with 16 hemodialysis patients revealed varied evaluations of life, focusing on attitudes towards limitations, mixed feelings regarding caregivers, and observable changes in personal character due to ESRF.
- The findings suggest that while ESRF and its treatment can lead to negative emotional states and character changes, some patients also reported positive developments, indicating potential areas for educational interventions to aid patient adjustment.
Patients' beliefs about illness are important because they influence adherence and adjustment, but they are often surprising and idiosyncratic. Qualitative research can identify them in ways that are not shaped by psychological theory, but quantification is necessary if clinicians are to be informed about the beliefs that are likely to be prevalent in their patients. Qualitative analysis of interviews with 16 haemodialysis (HD) patients identified beliefs about end-stage renal failure (ESRF) and its treatment that were formed into a questionnaire, completed by 156 similar patients.
View Article and Find Full Text PDFBackground: Cyclosporine (CsA) is a substrate for the MDR-1 gene product P-glycoprotein (P-gp). CsA efficacy may be modulated by lymphocyte P-gp expression levels. In this study, CsA inhibition of lymphocyte proliferation in whole-blood cultures ex vivo has been related to (1) lymphocyte P-gp expression and (2) the C3435T polymorphism in the MDR-1 gene, which has been reported to alter P-gp function.
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