Publications by authors named "Mike Bindschadler"

Background: Surgical management of pediatric patients with nonlesional, drug-resistant epilepsy, including patients with Lennox-Gastaut syndrome (LGS), remains a challenge given the lack of resective targets in most patients and shows seizure freedom rates <50% at 5 years. The efficacy of deep brain stimulation (DBS) is less certain in children than in adults. This study examined clinical and seizure outcomes for pediatric patients with LGS undergoing DBS targeting of the centromedian thalamic nuclei (CMTN).

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Article Synopsis
  • The study focuses on Robin Sequence (RS), a serious craniofacial condition leading to airway obstruction, emphasizing the need for accurate assessment of UAO severity in patients.
  • Researchers used advanced imaging and fluid dynamics techniques to discover significant variability in airway resistance and airflow patterns among RS patients, with some experiencing much more severe obstruction than others.
  • Findings indicate that specific airflow metrics can help correlate the severity of respiratory issues with the amount of clinical support needed, potentially enhancing understanding and management of UAO in RS patients.
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Modeling actin dynamics.

Wiley Interdiscip Rev Syst Biol Med

December 2010

Actin monomers assemble into filaments that structurally support cells as well as drive membrane protrusion for cell movement. Within cells, some actin structures are very dynamic and turn over rapidly, while others are very stable. Even purified actin filament dynamics are complex, and researchers have often turned to mathematical models in order to interpret data, test hypotheses, make predictions, and deepen understanding.

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