Publications by authors named "Mike B Comer"
J Pharmacol Exp Ther
August 2006
Article Synopsis
- - The study investigates the pharmacological effects of two novel PDE3/4 inhibitors, RPL554 and RPL565, which demonstrate significant inhibition of contractions in guinea pig tracheal preparations, indicating potential for respiratory applications.
- - Both compounds effectively suppress the release of inflammatory markers from human monocytes and reduce cell proliferation, showcasing their anti-inflammatory properties in various in vitro assays.
- - In vivo tests reveal that RPL554 and RPL565 substantially inhibit eosinophil recruitment and inflammation responses in guinea pigs, suggesting their promise as long-acting treatments for respiratory conditions.
