Publications by authors named "Mikayla Fraunfelder"
SPA Promotes Atherosclerosis Through Mediating Macrophage Foam Cell Formation-Brief Report.
Arterioscler Thromb Vasc Biol
November 2024
Article Synopsis
- Atherosclerosis is an inflammatory disease where macrophage foam cells contribute significantly to its progression, and surfactant protein A (SPA) has not been previously studied in this context.
- Research showed that SPA expression is higher in atherosclerotic tissues, and its deficiency reduces cholesterol levels and foam cell formation in macrophages, leading to decreased atherosclerosis.
- SPA promotes atherosclerosis by enhancing the expression of scavenger receptor CD36, which plays a key role in cholesterol accumulation in macrophages.
Article Synopsis
- Astrocytes can change their functions during and after a stroke, and understanding how these changes happen can lead to new treatments.
- The enzyme ADAR1, which is typically not found in astrocytes, increases significantly in these cells after a stroke and contributes to negative outcomes by promoting inflammation and neuron death.
- Lack of ADAR1 helps reduce brain damage and improve neurological functions after a stroke by lowering the activation of astrocytes and microglia, and preventing neuron apoptosis via inflammatory cytokines.
Background: Atherosclerosis is a progressive inflammatory disease where macrophage foam cells play a central role in the pathogenesis. Surfactant protein A (SPA) is a lipid-associating protein involved with regulating macrophage function in various inflammatory diseases. However, the role of SPA in atherosclerosis and macrophage foam cell formation has not been investigated.
View Article and Find Full Text PDFBlood serum analysis is a versatile tool used in diagnostics, research, and clinical studies. Enzyme-linked immunosorbent assay (ELISA) is a common method used to analyze blood serum cytokine levels; however, commercial kits are costly and not always available for novel or uncommon targets. Here we present a modified ELISA protocol that, once standardized, can be used to measure blood serum levels of any target and minimize the expense of commercial kits.
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