Publications by authors named "Mikaela L McKenney"
Metabolic syndrome (MetS) doubles the risk of adverse cardiovascular events. Glucagon-like peptide 1 (GLP-1) receptor agonists induce weight loss, increase insulin secretion, and improve glucose tolerance. Studies in healthy animals suggest cardioprotective properties of GLP-1 receptor agonists, perhaps partially mediated by improved sarco-endoplasmic reticulum Ca(2+) ATPase (SERCA) activity.
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- * Ossabaw miniature swine were fed a diet that promotes CAD, and EAT was surgically removed from a specific area of the heart to examine its effects on atherosclerosis progression.
- * Results indicated that the removal of EAT slowed CAD progression, suggesting that EAT may worsen the disease by promoting inflammation and other harmful processes in the coronary arteries.
Background: This investigation examined the mechanisms by which coronary perivascular adipose tissue (PVAT)-derived factors influence vasomotor tone and the PVAT proteome in lean versus obese swine.
Methods And Results: Coronary arteries from Ossabaw swine were isolated for isometric tension studies. We found that coronary (P=0.