Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening.

Amorphous drug nanosuspensions are prone to particle growth due to Ostwald ripening. By incorporating a second component of extremely low aqueous solubility, Ostwald ripening can be inhibited. These studies indicate that to inhibit ripening, the drug/inhibitor mixture (in the particles) must form a single phase.

Flocculation of microgel particles with sodium chloride and sodium polystyrene sulfonate as a function of temperature.

The flocculation behavior of poly(N-isopropylacrylamide) (PNIPAM) microgel particles, containing surface sulfate groups, has been studied as a function of sodium chloride [NaCl] concentration, between 0.1 and 800 mM NaCl and over the temperature range 25-60 degrees C. The critical flocculation temperature (CFT) of the particles was determined as a function of NaCl concentration.

A general gel layer model for the transport of colloids and macroions in dilute solution.

A general boundary element methodology for studying the dilute solution transport of rigid macroions that contain gel layers on their outer surfaces is developed and applied to several model systems. The methodology can be applied to particles of arbitrary size, shape, charge distribution, and gel layer geometry. Account is also taken of the steady state distortion of the ion atmosphere from equilibrium, which makes it applicable to the transport of highly charged structures.

The primary electroviscous effect of prolate silica sols.

The intrinsic viscosity and the dynamic mobility of four silica sols have been measured as a function of the ionic strength. It was found that intrinsic viscosity decreased with increasing ionic strength, which we attribute to the primary electroviscous effect. The geometry and the charge of the particles were fitted using experimental viscosity, light scattering, and dynamic mobility data, where the intrinsic viscosity measured at the highest ionic strength for a given sol was used as input data in our analysis.

The primary electroviscous effect, free solution electrophoretic mobility, and diffusion of dilute prolate ellipsoid particles (minor axis = 3 nm) in monovalent salt solution.

The principal objective of the present work is the modeling of the primary electroviscous effect of charged prolate ellipsoid models of low axial ratio. Other transport properties examined include (free solution) electrophoretic mobilities and translational diffusion constants. A numerical boundary element method is employed to solve the coupled Poisson, low Reynolds number Navier-Stokes, and ion transport equations.

Electroacoustic and Potentiometric Studies of the Hematite/Water Interface.

The basic charging properties of nearly spherical hematite particles were studied by using potentiometric titration and the electroacoustic technique. Both the pH and the ionic strength dependence of the surface charge and the zeta-potential were studied in detail. For calculating the zeta-potential from mobility data a few different theories were used and obtained differences are discussed.

Volume Fraction Effects in Electroacoustic Measurements.

We measured the dynamic mobility of a polystyrene latex at 1 MHz as a function of volume fraction using the ESA-8000. The volume fraction dependence is compared with a semiempirical equation as well as with some theoretical predictions. It turns out that our polystyrene latex exhibits a volume fraction dependence much weaker than that predicted by any of the theories.