Risk factors for loneliness among older informal caregivers in regions of Finland and Sweden: a longitudinal study.

Aims: This longitudinal study investigated the prevalence of and risk factors for loneliness among older new informal caregivers, long-term informal caregivers, former informal caregivers and non-caregivers in selected regions of Finland and Sweden over 5 years.

Methods: A longitudinal sample of 5083 respondents from the Gerontological Regional Database (GERDA) survey data in 2016 and 2021 was used. Bivariate correlation tests and multivariate logistic regression analyses were performed.

Does social capital enhance political participation in older adults? Multi-level evidence from the European Quality of Life Survey.

This study explored the role of social capital for non-institutionalised and institutionalised political participation among older adults compared to younger age groups using European Quality of Life Survey data (EQLS) from 2016 and 33 countries (n = 36,908). Multilevel logistic regression analysis was employed to assess the association between individual- and country-level social capital and political participation. Findings revealed that, at the individual level, active associational engagement was positively related to both forms of political participation, while social trust and political trust were linked only to non-institutionalised participation-higher social trust and lower political trust were associated with a greater likelihood of participation.

A problem of gendered injustice? Objective and subjective poverty among older women and men across European welfare regimes.

Using European Social Survey data, this article studies the prevalence of objective and subjective poverty among older women and men (60+ years) in 21 European countries. Objective poverty refers to whether one's disposable income falls below the poverty line, whereas subjective poverty relates to the capacity to make ends meet. It analyzes gender differences in these two dimensions of poverty and the role of gender as an explanation to these phenomena while controlling for other individual-level variables as well as the role of welfare state regimes.

A Cross-Sectional Study on the Associations between Economic, Social, and Political Resources and Subjective Caregiver Burden among Older Spousal Caregivers in Two Nordic Regions.

Inspired by the caregiver stress process model emphasising the role of resources for caregiving outcomes, the aim of this study was to investigate the prevalence of subjective caregiver burden (SCB) and its associations with individual social, economic, and political resources among older spousal caregivers in a Nordic regional setting. Cross-sectional survey data collected in 2016 in the Bothnia region of Finland and Sweden were used, where 674 spousal caregivers were identified and included in the analyses. The descriptive results showed that about half of the respondents experienced SCB.

Morale in Old Age and Its Association with Sociodemographic, Social, and Health-Related Factors in Different Age Groups.

Morale can be viewed as a future-oriented optimism or pessimism regarding challenges associated with aging and is closely related to subjective well-being. Promoting morale in old age could be considered to have important implications for aging well, and increased knowledge about morale in different stages of old age is needed. Hence, the aim of this study was to investigate factors associated with morale in different age groups among old people.

Risk factors for a decrease in high morale in very old people over a 5-year period: data from two Nordic countries.

High morale could be considered to be an essential part of aging well and increased knowledge of how to prevent a decrease in high morale in very old age could have important implications for policy, and social and health care development. The objective was to identify social and health-related risk factors for a decrease in morale over 5 years in very old people among those with high morale at baseline. The study is based on data derived from the Umeå85+/GERDA study conducted in Northern Sweden and Western Finland.

Loneliness amongst older people in Europe: a comparative study of welfare regimes.

Previous research implies that the extent of welfare state regime provision plays an important indirect role in the prevalence of loneliness in later life. The aim of this study was therefore to assess the association between quality of living conditions and level of social integration indicators and the absence of loneliness in five different welfare regimes. By incorporating welfare state regimes as a proxy for societal-level features, we expanded the micro-level model of loneliness suggesting that besides individual characteristics, welfare state characteristics are also important protective factors against loneliness.

Five-year change in morale is associated with negative life events in very old age.

Objectives: The objectives were to study changes in morale in individuals 85 years and older, and to assess the effect of negative life events on morale over a five-year follow-up period.

Method: The present study is based on longitudinal data from the Umeå85+/GERDA-study, including individuals 85 years and older at baseline (n = 204). Morale was measured with the Philadelphia Geriatric Center Morale Scale (PGCMS).

Leisure Engagement: Medical Conditions, Mobility Difficulties, and Activity Limitations-A Later Life Perspective.

Objectives. This study aims to investigate the impact of medical conditions, mobility difficulties, and activity limitations on older people's engagement in leisure activities. Methods.

Social capital and self-rated health amongst older people in Western Finland and Northern Sweden: a multi-level analysis.

Background: Social capital can be conceptualised as an individual resource residing in relationships between individuals or as a collective resource produced through interactions in neighbourhoods, communities or societies. Previous studies suggest that social capital is, in general, good for health. However, there is a shortage of studies analysing the association between individual and collective social capital in relation to health amongst older people.

Social participation, interpersonal trust, and health: a study of 65- and 75-year-olds in western Finland.

Aim: To study the association between social participation, interpersonal trust, and self-rated health among 65- and 75-year-olds.

Methods: The data originates from a cross-sectional postal questionnaire survey conducted among 1577 persons aged 65 and 75 years in western Finland (response rate 67%). Logistic regression analyses were performed in order to investigate the association between social capital--in terms social participation and interpersonal trust--and health while controlling for sociodemographic variables.

Glial transcripts and immune-challenged glia in the suprachiasmatic nucleus of young and aged mice.

Biological rhythms are frequently disturbed with advancing age, and aging-related changes of glia in the hypothalamic suprachiasmatic nucleus (SCN), the master circadian pacemaker, require special attention. In particular, astrocytes contribute to SCN function, and aging is associated with increased inflammatory activity in the brain, in which microglia could be especially implicated. On this basis, we investigated in the SCN of young and old mice glial transcripts and cell features, and the glial cell response to a central inflammatory challenge.

Clock gene expression during chronic inflammation induced by infection with Trypanosoma brucei brucei in rats.

African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma brucei brucei (Tb brucei), to study the effects on clock gene expression.

Plasma levels of interferon-gamma correlate with age-related disturbances of circadian rhythms and survival in a non-human primate.

Aging can be associated with changes in circadian rhythms and reduction in adaptive immune responses accompanied by expansion of memory T cells and elevated levels of pro-inflammatory cytokines. Recent findings suggest the cytokine interferon-gamma (IFN-gamma) can affect the function of the hypothalamic suprachiasmatic nucleus (SCN), the master mammalian circadian pacemaker, both in vitro and in vivo. We studied the correlation of plasma levels of IFN-gamma and changes in circadian rhythms in a non-human primate species, the nocturnal mouse lemur (Microcebus murinus).

African trypanosome infections of the nervous system: parasite entry and effects on sleep and synaptic functions.

The extracellular parasite Trypanosoma brucei causes human African trypanosomiasis (HAT), also known as sleeping sickness. Trypanosomes are transmitted by tsetse flies and HAT occurs in foci in sub-Saharan Africa. The disease, which is invariably lethal if untreated, evolves in a first hemo-lymphatic stage, progressing to a second meningo-encephalitic stage when the parasites cross the blood-brain barrier.

Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge.

Aging is often accompanied by increased levels of inflammatory molecules in the organism, but age-related changes in the brain response to inflammatory challenges still require clarification. We here investigated in mice whether cytokine signaling and T-cell neuroinvasion undergo age-related changes. We first analyzed the expression of molecules involved in T-cell infiltration and cytokine signaling regulation in the septum and hippocampus of 2-3 months and 20- to 24-month-old mice at 4h after intracerebroventricular injections of tumor necrosis factor (TNF)-alpha or interferon-gammaversus saline injections.

Rapid nitric oxide-dependent effects of tumor necrosis factor-alpha on suprachiasmatic nuclei neuronal activity.

The effect of tumor necrosis factor-alpha (TNF-alpha) on excitability and synaptic function was analyzed in slice preparations of the suprachiasmatic nuclei (SCN), the major mammalian circadian pacemaker. TNF-alpha caused a rapid increase in the spontaneous firing rate in most SCN neurons examined that was paralleled by an increase of inhibitory postsynaptic currents. The nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester abolished these effects.

Decline of the presynaptic network, including GABAergic terminals, in the aging suprachiasmatic nucleus of the mouse.

Biological rhythms, and especially the sleep/wake cycle, are frequently disrupted during senescence. This draws attention to the study of aging-related changes in the hypothalamic suprachiasmatic nucleus (SCN), the master circadian pacemaker. The authors here compared the SCN of young and old mice, analyzing presynaptic terminals, including the gamma-aminobutyric acid (GABA)ergic network, and molecules related to the regulation of GABA, the main neurotransmitter of SCN neurons.

The aging suprachiasmatic nucleus and cytokines: functional, molecular, and cellular changes in rodents.

The aging process brings about a switch to a low-grade chronic inflammatory condition in the periphery and brain, a condition which may prime brain cells, including those of the hypothalamic suprachiasmatic nucleus (SCN). Little information is available, however, on the responses of the SCN to neuroinflammation and immune-related challenges, and such responses have not been hitherto investigated during aging. We here provide an overview of these issues and summarize data we obtained in the study of the SCN of young and aged mice.

The GABAergic network in the suprachiasmatic nucleus as a key regulator of the biological clock: does it change during senescence?

GABA is the main neurotransmitter of the hypothalamic suprachiasmatic nucleus (SCN) and plays a key role in the function of this master circadian pacemaker. Despite the evidence that disturbances of biological rhythms are common during aging, little is known about the GABAergic network in the SCN of the aging brain. We here provide a brief overview of the GABAergic structures and the role of GABA in the SCN.

Suppressors, receptors and effects of cytokines on the aging mouse biological clock.

During aging, levels of inflammatory cytokines increase and circadian rhythms are frequently altered. We here investigated neurobiological correlates of neuroinflammation and its age-related variation in the hypothalamic suprachiasmatic nucleus (SCN), the master circadian pacemaker. Day/night variations of transcripts encoding cytokine receptors and suppressors of cytokine signaling (SOCS) were correlated in groups of mice of different ages with Fos induction elicited by intracerebroventricular injections of tumor necrosis factor-alpha and interferon-gamma.

Age-related changes in electrophysiological properties of the mouse suprachiasmatic nucleus in vitro.

Endogenous biological rhythms are altered at several functional levels during aging. The major pacemaker driving biological rhythms in mammals is the suprachiasmatic nucleus of the hypothalamus. In the present study we used tissue slices from young and old mice to analyze the electrophysiological properties of the retinorecipient ventrolateral part of the suprachiasmatic nucleus.