Publications by authors named "Mikael Le Dantec"
Background: Prolonged, altered hematopoietic reconstitution is commonly observed in patients undergoing myeloablative conditioning and bone marrow and/or mobilized peripheral blood-derived stem cell transplantation. We studied the reconstitution of myeloid and lymphoid compartments after the transplantation of autologous CD34+ bone marrow cells following gamma irradiation in cynomolgus macaques.
Results: The bone marrow cells were first transduced ex vivo with a lentiviral vector encoding eGFP, with a mean efficiency of 72% +/- 4%.
Article Synopsis
- Infection with HIV-1 and SIV in primates leads to significant issues in blood cell production, which are linked to problems in bone marrow function.
- Research shows that during SIV infection in macaques, hematopoietic progenitor cells lose their ability to develop into multiple blood cell types due to decreased levels of proteins STAT5A and STAT5B; however, restoring STAT5B expression can reverse this loss.
- The viral protein Nef plays a crucial role in this impairment and works by affecting the PPARgamma pathway, suggesting that drugs targeting PPARgamma could be potential treatments for AIDS and related blood disorders.