Transmembrane nanopores from porphyrin supramolecules.

A porphyrin-based nanopore was constructed through a bilayer lipid membrane (BLM). The macrocyclic porphyrin (the inner diameter = ca. 2.

Supramolecular ion channels from a transmembrane bischolic acid derivative showing two discrete conductances.

Bischolic acid derivative 1 linked by m-xylylene dicarbamate at the 3,3'-position was synthesized and the single ion channel properties were examined. Compound 1 showed two clearly distinct conductances, 9.5 (type A) and 25.

Tetracyanoresorcin[4]arene ion channel shows pH dependent conductivity change.

A pH sensitive artificial ion channel, tetracyanoresorcin[4]arene, whose pK(a1) to pK(a3) are around pH 7, was synthesized. Conductivities for potassium ion were increased by the progress of dissociation at the channel mouth.