Two new furanoeremophilane sesquiterpenoids from Ligularia oligonema.

From the roots of Ligularia oligonema and an unidentified sample of Ligularia collected in Yunnan Province of China, two new sesquiterpenoids, 3beta-acetoxy-6beta-(2-methylbutyryloxy)furanoeremophilan-10beta-ol and 3beta-acetoxy-6beta-isobutyryloxyfuranoeremophilan-10beta-ol, were isolated. DNA sequencing showed that the unidentified sample was likely to be L. oligonema.

High diversity of Ligularia dictyoneura in chemical composition and DNA sequence.

The chemical composition of root extracts of the title species collected at 20 different places in the Hengduan Mountains of China was examined. From these samples, a total of 17 eremophilane derivatives were isolated, three of which were new franoeremophilane derivatives: 3beta-acetoxy-6beta-(angeloyloxy)furanoeremophilan-10beta-ol, 1alpha-acetoxyfuranoeremophilan-15,6alpha-olide, and 6beta-[2-(hydroxymethyl)prop-2-enoyloxy]furanoeremophil-1(10)-ene. Based on the chemical composition, the samples could be classified into as many as seven types: one type containing non-furanoeremophilane derivatives and the other six containing furanoeremophilane derivatives with different oxidation levels.