-Selective Synthesis and Coordination Chemistry of Pyridine-Phosphaalkenes: Five Ligands Produce Four Distinct Types of Ru(II) Complexes.

Pyridine-phosphaalkene (PN) ligands were prepared in an -selective fashion using phospha-Wittig methodology. Treatment of these five ligands, varying only in their 6-substituent with RuCl(PPh), produced four distinct types of coordination complexes: pyridine-phosphaalkene-derived , cyclized , and six-coordinate and . Prolonged heating of in THF resulted in C-H activation of the Mes* group and cyclization to give featuring a bidentate pyridine-phospholane ligand bound to the metal center.

Englerin a selectively induces necrosis in human renal cancer cells.

The number of renal cancers has increased over the last ten years and patient survival in advanced stages remains very poor. Therefore, new therapeutic approaches for renal cancer are essential. Englerin A is a natural product with a very potent and selective cytotoxicity against renal cancer cells.