Rational Fabrication of Copper Nanoclusters and In Vitro Study of Antioxidant Property.

Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and antioxidants, is a critical factor in the pathogenesis of a wide range of diseases. The excessive accumulation of ROS can cause severe cellular damage, leading to tissue dysfunction and disease progression. The development of nanomaterials with antioxidant properties presents a promising strategy for addressing this challenge.

Self-regulating immunosuppressive tumor microenvironment by NIR-II photothermal agent with anti-inflammatory activity for self-reinforcing immunotherapy synergy with cancer photothermal ablation.

Cancer thermal immunotherapeutic strategy has garnered tremendous attention in nanomedicine frontier. Photothermal therapy (PTT) within the second near-infrared (NIR-II) window is popular hyperthermia technique, but the effect of NIR-II PTT on antitumor immunity remains extensive exploration. Here, we first reveal the inflammatory immunosuppressive tumor microenvironment (TME) characterized by high-influx of myeloid-derived suppressor cells (MDSCs) following NIR-II PTT.