Publications by authors named "Mihtikar Guersel"
Introduction: Blood-based biomarkers are a cost-effective and minimally invasive method for diagnosing the early and preclinical stages of amyloid positivity (AP). Our study aims to investigate our novel immunoprecipitation-immunoassay (IP-IA) as a test for predicting cognitive decline.
Methods: We measured levels of amyloid beta (Aβ)X-40 and AβX-42 in immunoprecipitated eluates from the DELCODE cohort.
Background And Objectives: 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer's disease (AD) research. Sex and obesity effects on TSPO-PET binding have been reported for cognitively normal humans (CN), but such effects have not yet been systematically evaluated in patients with AD. Thus, we aimed to investigate the impact of sex and obesity on the relationship between β-amyloid-accumulation and microglial activation in AD.
View Article and Find Full Text PDFβ-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer's disease (AD), and biomarkers for these hallmarks have been linked to neuroinflammation. However, the detailed regional associations of these biomarkers with microglial activation in individual patients remain to be elucidated. We investigated a cohort of 55 patients with AD and primary tauopathies and 10 healthy controls that underwent TSPO-, Aβ-, tau-, and perfusion-surrogate-PET, as well as structural MRI.
View Article and Find Full Text PDFBackground: Cognitive reserve (CR) explains inter-individual differences in the impact of the neurodegenerative burden on cognitive functioning. A residual model was proposed to estimate CR more accurately than previous measures. However, associations between residual CR markers (CRM) and functional connectivity (FC) remain unexplored.
View Article and Find Full Text PDFArticle Synopsis
- Alzheimer's disease (AD) affects brain connectivity, but how lifelong experiences (cognitive reserve or CR) relate to this is not well-understood.
- A study analyzed brain scans of 228 participants, including healthy individuals and those at various AD stages, focusing on the default-mode network's connectivity.
- Results showed that higher lifetime experiences scores were linked to better connectivity in the brain's default-mode network, suggesting that engaging in various activities may help preserve cognitive function even as memory declines.
Article Synopsis
- - The study investigates how microglial activation, which is linked to neuroinflammation in Alzheimer's disease (AD), relates to the connectivity of brain regions in Aβ-positive early AD patients compared to healthy controls.
- - Utilizing advanced imaging techniques like positron emission tomography (PET) and magnetic resonance imaging (MRI), researchers found that microglial activation was more prominent in functionally connected brain areas in AD patients, correlating with cognitive decline.
- - The findings suggest that, similar to tau pathology, microglial activation spreads along highly interconnected brain pathways, highlighting its potential role in the progression of neurodegeneration in AD.