Publications by authors named "Mihoko Hatano"
Synovial sarcoma (SS) is a rare high-grade malignant mesenchymal tumour with a relatively poor prognosis despite intensive multimodal therapy. Although pazopanib, a multi-kinase inhibitor, is often used for advanced SS, most cases eventually become resistant to pazopanib. In the present study, we investigated the mechanisms of acquired pazopanib resistance in SS.
View Article and Find Full Text PDFCadherin-11 regulates the metastasis of Ewing sarcoma cells to bone.
Clin Exp Metastasis
August 2015
Ewing sarcoma (ES) is a small round-cell tumor of the bones and soft tissues. ES frequently causes distant metastases, particularly in the lung and bone, which worsens patient prognosis. Cadherin-11 (Cad-11) is an adhesion molecule that is highly expressed in osteoblasts.
View Article and Find Full Text PDFArticle Synopsis
- This study explores the role of microRNAs, particularly miR-125b, in developing chemoresistance in Ewing sarcoma (EWS).
- Researchers identified that miR-125b was upregulated in doxorubicin-resistant EWS cell lines and in tumors that survived chemotherapy.
- Knocking down miR-125b increased sensitivity to doxorubicin and was linked to the activation of pro-apoptotic molecules p53 and Bak, suggesting miR-125b may inhibit apoptosis and promote drug resistance.