Publications by authors named "Miho Sakaida"
Article Synopsis
- Donor lymphocyte infusion (DLI) can effectively treat relapsed hematological cancers by fostering a graft-versus-tumor effect, but it carries risks such as graft-versus-host disease and pulmonary complications.
- Pulmonary complications following DLI can be linked to viral infections, with poorly understood mechanisms, making diagnosis difficult without invasive procedures like bronchoalveolar lavage.
- A specific case of a 62-year-old man reveals that infections from viruses like Human-Rhinovirus (HRV) and Enterovirus (EnV) can lead to serious respiratory issues after DLI, emphasizing the importance of controlling viral replication rather than just inflammation in treatment.
Article Synopsis
- Eosinophilic gastrointestinal disorders (EGIDs) are rare but can occur after allogeneic hematopoietic cell transplantation (allo-HCT), particularly when the donor has allergic conditions.
- In a study involving two patients with acute leukemia, both developed food allergies post-cord blood transplantation, leading to eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE).
- The cases emphasize that unexpected food allergy acquisition after transplantation can lead to EGIDs, particularly in individuals receiving T-cell non-depletion graft-versus-host disease (GVHD) prophylaxis, with non-steroidal dietary treatment proving effective.
Although diffuse large B-cell lymphoma (DLBCL) occasionally lacks surface immunoglobulin light chain restriction (iLCR) on flow cytometry (FCM), little evidence is available for iLCR-negative DLBCL. We retrospectively compared clinicopathological features of iLCR-positive and iLCR-negative DLBCL diagnosed at our institute between April 2007 and March 2018. iLCR-positive was defined as a κ/λ ratio less than 0.
View Article and Find Full Text PDFWe report a case of rhabdoid tumor predisposition syndrome with a renal tumor developing 10 years after a brain tumor, which demonstrated an unexpectedly favorable outcome. A 2-year-old boy underwent gross total resection of a brain tumor located in the fourth ventricle, and received adjuvant chemotherapy and radiotherapy. At the age of 11 years, a renal tumor was found and nephrectomy was performed.
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