Zn Complex of Diaminedithiol Tetradentate Ligand as a Stable Precursor for Tc-Labeled Compounds.

The diaminedithiol (NS) tetradentate ligand constitutes a useful chelating molecule for preparing Tc-labeled compounds of high in vivo stability in high radiochemical yields. However, since the thiol groups in the NS ligand are easy to be oxidized to disulfide bonds, they need to be protected with an appropriate protecting group, which hinders the broad applications of the NS ligand for radiopharmaceuticals. In this study, a Zn chelate of NS was evaluated as a precursor for purification-free Tc-labeled NS under the mild and simple procedure.

Noninvasive estimation of quantitative myocardial blood flow with Tc-99m MIBI by a compartment model analysis in rat.

Background: We aimed to investigate the use of dynamic cardiac planar images to estimate myocardial blood flow (MBF) by a compartment model analysis using time-to-peak (TP) map and compared it by the microsphere technique in rat. Positron emission tomography is considered the gold standard method, but is not available everywhere. By contrast, although myocardial perfusion imaging (MPI) with single-photon tracers is more widely available, it may be difficult to obtain adequate region of interest (ROI) settings.