Phenotypic analysis of mice xenografted with canine epitheliotropic cutaneous T-cell lymphoma cells.

Background: In canine epitheliotropic cutaneous T-cell lymphoma (ECTCL), neoplastic cells cause skin lesions and potentially metastasize to lymph nodes, blood and other organs. Murine models are potentially valuable for elucidating the molecular mechanisms responsible for regulation of ECTCL cell migration.

Hypothesis/objectives: To describe a phenotype of mice xenografted with canine ECTCL cells (EO-1 cells).