Publications by authors named "Miho Iida"

Objectives: Underweight or obesity is associated with infertility in women, but large cohort studies with a life course perspective are rare. We explored the association between body mass index (BMI) at age 18 and subsequent infertility among Japanese women.

Study Design: In total, 15,907 married women aged 30-44 years who participated in a prospective cohort baseline survey during 2001-2007 were cross-sectionally analyzed.

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Purpose: Hypertension (HT), dyslipidemia (DL), and diabetes mellitus (DM) are major risk factors for cardiovascular diseases. Despite the wide availability of medications to reduce this risk, poor adherence to medications remains an issue. The aim of this study is to evaluate medication adherence of prevalent users in these disease medications (HT, DL, DM) using claims data.

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Objectives Although self-reported questionnaires are widely used to collect information on medication use in epidemiological studies, their validity for studies involving older adults has not been sufficiently assessed. This study evaluated the validity of self-reported medication use using questionnaires in comparison with drug notebooks.Methods The study enrolled 370 older community dwellers who participated in an aging sub-study survey of the Tsuruoka Metabolomics Cohort Study between April 2019 and March 2021.

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  • The study focuses on using metabolomics profiles in urine and plasma to improve health risk assessments for low-level cadmium exposure in a large population sample.
  • Researchers analyzed 123 urinary and 94 plasma metabolites from over 3,400 participants, adjusting for various factors like age, gender, and lifestyle choices.
  • Findings indicated that certain urinary metabolites, especially N-acetyl-beta-D-glucosaminidase (NAG), were linked to cadmium levels, with specific metabolites showing consistent associations across different exposure levels and pathways related to mitochondria being affected.
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  • The study investigates the link between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis, specifically looking at the cardio-ankle vascular index (CAVI) as an indicator of early atherosclerosis.
  • Using a sample of 928 Japanese individuals, researchers examined the relationship through statistical models and analyzed 94 plasma metabolites to identify any associations.
  • Results revealed a positive correlation between NAFLD and CAVI, with ten key metabolites, such as branched-chain and aromatic amino acids, possibly mediating this relationship and suggesting a role of insulin resistance in the progression from NAFLD to atherosclerosis.
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Background: Menopausal disorders include obscure symptomatology that greatly reduce work productivity among female workers. Quantifying the impact of menopause-related symptoms on work productivity is very difficult because no such guidelines exist to date. We aimed to develop a scale of overall health status for working women in the perimenopausal period.

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Studies examining long-term longitudinal metabolomic data and their reliability in large-scale populations are limited. Therefore, we aimed to evaluate the reliability of repeated measurements of plasma metabolites in a prospective cohort setting and to explore intra-individual concentration changes at three time points over a 6-year period. The study participants included 2999 individuals (1317 men and 1682 women) from the Tsuruoka Metabolomics Cohort Study, who participated in all three surveys-at baseline, 3 years, and 6 years.

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  • The Tsuruoka Metabolomics Cohort Study (TMCS) is a large-scale, ongoing research project in rural Japan aiming to improve disease prevention strategies for complex illnesses by analyzing risk factors and predictors.
  • The study includes 11,002 participants aged 35-74 from Tsuruoka City, who provide extensive health and lifestyle data and undergo molecular profiling to identify potential disease-linked biomarkers.
  • TMCS focuses on outcomes related to cardiovascular diseases, cancer, and aging effects, utilizing a multi-omics approach to capture comprehensive biological, behavioral, and social data, and boasts a high participation rate and robust study design.
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Background: Heated tobacco products (HTPs) have gained global popularity, but their health risks remain unclear. Therefore, the current study aimed to identify plasma metabolites associated with smoking and HTP use in a large Japanese population to improve health risk assessment.

Methods: Metabolomics data from 9,922 baseline participants of the Tsuruoka Metabolomics Cohort Study (TMCS) were analyzed to determine the association between smoking habits and plasma metabolites.

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This study explored the factors associated with healthcare avoidance behavior for menstrual disorders and menopausal symptoms among women in Japan. Using data from a nationally representative cross-sectional online survey conducted in September 2022, responses from 4,950 women aged 25-59 were analyzed. This study applied binomial logistic regression models specifically to participants who reported having ever felt the need to seek healthcare assistance due to health issues related to menstruation and menopause.

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Objective: We aim to investigate the quantity and quality of scientific evidence dealing with comprehensive health issues of working women in occupational health.

Methods: This scoping review of original articles that investigated comprehensive health issues of working women aged 19-64 years in Japan was published in PubMed (1967-2022) and Igaku Chuo Zasshi (or Ichu-shi, 1982-2022). Using identical broad search terms, we first identified 17 122 English and 6154 Japanese articles.

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Unlabelled: Ovarian cancer has a poor prognosis and is difficult to detect in early stages. Therefore, developing new diagnostic markers for early-stage ovarian cancer is critical. Here, we developed a diagnostic marker for early-stage ovarian cancer on the basis of fatty acid metabolism characteristics of cancer cells.

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Purpose: This study aimed to examine the association between sleep duration and quality and sarcopenia, assessed by factors such as low muscle mass (LMM), low muscle strength (LMS), and low physical performance (LPP) among older community-dwellers in Japan.

Methods: In this cross-sectional study, a total of 2,069 (men, 902; women, 1,167) participants aged 65 to 80 years were included. Sarcopenia and each low physical function were defined using the definitions of the Asian Working Groups of Sarcopenia 2019.

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Introduction: Little is known about the association between hypospadias and small fetuses, as well as the pathological implications of fetal growth restriction (FGR). Thus, we aimed to investigate the association between hypospadias and small fetuses using a database of fetal ultrasound and obstetric events.

Methods: A cohort of male singleton infants delivered after 22 weeks of gestation at Keio University Hospital between 2013 and 2019 was retrospectively reviewed.

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  • The study examines the link between unhealthy behaviors and insomnia among Japanese adults aged 35-74.
  • It analyzes data from 9,565 participants, looking at factors like exercise habits, smoking, alcohol consumption, breakfast skipping, and obesity.
  • Results show that both men and women with multiple unhealthy behaviors have a higher likelihood of experiencing insomnia, particularly those without major cardiovascular risk factors.
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Background: Progress in reducing the global low birthweight (LBW) has been insufficient. Although the focus has been on preventing preterm birth, evidence regarding LBW in term births is limited. Despite its low preterm birth prevalence, Japan has a higher LBW proportion than other developed countries.

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Radical hysterectomy is often performed to treat early-stage cervical cancer in women of reproductive age, and sexual dysfunction due to postoperative vaginal shortening is a major concern [1,2]. Vaginoplasty using various techniques is commonly performed in patients with congenital vaginal agenesis [3]. However, there are few reports of vaginoplasty being performed for vaginal shortening after radical hysterectomy in a patient with cervical cancer [4,5].

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Various vaginoplasty procedures have been developed for patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Here, we describe a novel laparoscopic vaginoplasty procedure, known as the Kisu modification, using a pull-down technique of the peritoneal flaps with additional structural support to the neovaginal apex using the incised uterine strand in patients with MRKH syndrome. Ten patients with MRKH syndrome (mean age at surgery: 23.

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Background: Emerging evidence has shown that charged metabolites, such as amino acids, may play an important role in the pathogenesis of various metabolic disorders, many of which women in the postmenopausal period are at high risk of developing. This study examined the metabolic profile of middle-aged Japanese women to investigate alterations in charged metabolites induced by menopausal transition.

Methods: The participants were 1193 female residents aged 40-60 at the baseline survey of the Tsuruoka Metabolomics Cohort Study.

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Ureteral injuries are well-known complications of gynecologic surgery, with a higher prevalence in laparoscopic surgery than in laparotomy [1]. The use of near-infrared fluorescent imaging navigation is currently being considered a novel method to identify the ureters intraoperatively and prevent ureteral injuries [2]. The Near-Infrared Ray Catheter (NIRC) fluorescent ureteral catheter is a newly developed device, containing a fluorescent resin that can be recognized by near-infrared irradiation.

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Article Synopsis
  • A longitudinal study in Japan examined the rise of heated tobacco products (HTPs) and its impact on smoking habits and lung function (measured by forced expiratory volume or FEV) among different groups of smokers over time.
  • The study involved two populations: a resident group of older adults (average age 67.7) and a worksite group (average age 49.3), categorizing participants into various smoking groups (cigarette-only, HTP-only, dual users, past smokers, and never smokers).
  • Results showed that dual users of HTPs and cigarettes had increased tobacco consumption and more significant FEV decline compared to those who smoked only cigarettes, highlighting a need for tobacco policies that address the risks
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Objective: The pelvic lymphatic drainage system comprises the upper and lower paracervical pathways (LPPs). Lymph node dissection of the LPP, including the cardinal ligament, internal iliac, internal common iliac, and presacral lymph nodes, requires higher surgical skills because of the anatomical limitations of the pelvic cavity and the dissection of vessels while preserving the nerves in the pelvic floor. In this video, we demonstrate rectal mobilization for laparoscopic complete pelvic lymph node dissection of the LPP in patients with uterine cancer.

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