Publications by authors named "Mihir P Paralkar"
Article Synopsis
- - This study explores how tumor neoantigens can be prioritized for cancer immunotherapy by introducing four metrics to assess peptide novelty, comparing tumors to normal tissues and other peptides, to improve predictions of neoantigenicity.
- - The research analyzes data from The Cancer Genome Atlas (TCGA) and melanoma patients, finding that neoepitope burden varies by disease type and HLA alleles, with many neoepitopes showing low similarity across patients.
- - Results indicate that only a small percentage (20.3%) of predicted neoepitopes show unique binding changes, with many being more similar to human, bacterial, or viral peptides rather than their normal tissue counterparts, leading to new insights in immune response correlations.
