Publications by authors named "Mihatovic I"
Objectives: To assess the clinical performance of an equine-derived collagen-containing bone block (CXBB) for lateral alveolar ridge augmentation and staged implant placement.
Material And Methods: A total of n = 16 patients (16 implants) had received a modified surgical protocol for lateral ridge augmentation using a size-adapted rigidly fixed CXBB and contour augmentation. After 26 weeks of submerged healing, the primary endpoint was defined as the final ridge width (RW26) sufficient to place an adequately dimensioned titanium implant at the respective sites.
Objectives: The aim of the present randomized, controlled clinical multicenter trial was to compare a polyethylene glycol (PEG) and a native collagen membrane (BG) for simultaneous guided bone regeneration at bony dehiscence-type defects around bone level titanium implants.
Material And Methods: The study enrolled 117 patients requiring implant treatment in the posterior maxilla or mandible with expected buccal bony dehiscence-type defects at the placed titanium implants. According to a parallel groups design, defects were filled with a synthetic bone filler and randomly assigned to either PEG or BG membrane.
Background: To assess the influence of ridge preservation procedures on the healing of extraction sockets under antiresorptive therapy.
Material And Methods: A total of 10 Dutch Belted rabbits were randomly allocated to either the intravenous administration of amino-bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (no Za [nZa]) (n = 5). At 6 months, the mandibular and maxillary molars were extracted and the four experimental sites randomly allocated to the following subgroups: (a) socket grafting using a collagen-coated natural bone mineral (BOC) + primary wound closure, (b) coronectomy (CO), or (c) spontaneous healing + primary wound closure (SP).
Objective: To assess the influence of biphasic calcium phosphate materials with different surface topographies on bone formation and osseointegration of titanium implants in standardized alveolar ridge defects.
Materials And Methods: Standardized alveolar ridge defects (6 × 6 mm) were created in the mandible of 8 minipigs and filled with three biphasic calcium phosphate materials (BCP1-3, 90% tricalcium phosphate/10% hydroxyapatite) with different surface properties (micro- and macroporosities) as well as a bovine-derived natural bone mineral (NBM) as a control. At 12 weeks, implants were placed into the augmented defects.
Objectives: Whereas stationary stability of implants has been postulated for decades, recent studies suggested a phenomenon termed implant migration. This describes a change in position of implants as a reaction to applied forces. The present study aims at employing image registration of in vivo micro-CT scans from different time points and to assess (a) if migration of continuously loaded implants is possible and (b) migration correlates with the force magnitude.
View Article and Find Full Text PDFObjectives: To assess the influence of autoclavation on the efficacy of extracted tooth roots (TR) used for vertical alveolar ridge augmentation and two-stage osseointegration.
Material And Methods: Maxillary premolars were randomly assigned to either autoclavation (TR-A) or were left untreated (TR-C) and used as block grafts for vertical alveolar ridge augmentation in both lower quadrants (n = 4 beagle dogs). At 12 weeks, titanium implants were inserted and left to heal for 3 weeks.
Objectives: Previous research revealed that autogenous tooth roots may be biologically equivalent to conventional bone grafts for lateral ridge augmentation. However, these analyses were limited to two dimensions, whereas healing is a volumetric process. The present study aimed at volumetrically assessing the microstructure following lateral ridge augmentation using extracted tooth roots.
View Article and Find Full Text PDFObjectives: To assess the clinical safety and performance of collagenated xenogeneic bone block (CXBB) for lateral alveolar ridge augmentation and two-stage implant placement.
Material & Methods: In ten patients exhibiting a single-tooth gap, the surgical procedure included the preparation of mucoperiosteal flaps, a rigid fixation of CXBB (Geistlich Bio-Graft ) using an osteosynthesis screw, and contour augmentation. After 24 weeks of submerged healing, the primary endpoint was defined as the final ridge width sufficient to place an adequately dimensioned titanium implant at the respective sites.
Objectives: This study seeks to assess the bone tissue response at experimental zirconia implants in comparison with titanium implants by means of descriptive histology and histomorphometry in a dog model.
Materials And Methods: Experimental zirconia implants with three different surface roughnesses (Z1 < Z2 < Z3) and conventional sandblasted large grit and acid-etched titanium implants were inserted bilaterally in the lower jaws of nine beagle dogs. Tissue biopsies were obtained after 3 and 14 days and 10 weeks of transmucosal healing.
Objectives: To assess the efficacy of periodontally diseased tooth roots used as autografts for lateral ridge augmentation and two-stage early osseointegration of titanium implants.
Material And Methods: Ligature-induced periodontitis lesions were established at the maxillary premolars in n = 8 foxhounds. Extracted, scaled and root planed pre-molar roots (PM-P) as well as retromolar cortical autogenous bone (AB) blocks were used for horizontal ridge augmentation of mandibular chronic-type defects.
Objectives: To assess biomechanical, micro-computed tomographic (micro CT) and immunohistochemical characteristics of early osseous integration at titanium implants placed following lateral ridge augmentation using autogenous extracted tooth roots.
Material & Methods: The roots of healthy maxillary premolars (PM) and retromolar cortical autogenous bone (AB) blocks were used for lateral ridge augmentation at chronic-type defects in the lower quadrants of n = 16 foxhounds. At 12 weeks, titanium implants were inserted and left to heal for another 3 weeks.
Objectives: To assess the efficacy of tooth roots used as autografts for lateral ridge augmentation and two-stage early osseointegration of titanium implants.
Material & Methods: The maxillary premolars were randomly assigned to either endodontic therapy (PM-E) or were left untreated (PM-C). Retromolar cortical autogenous bone (AB) blocks served as controls.
Objectives: The success of ridge preservation techniques in reducing bone resorption is well documented, but no clear guidelines have been provided regarding the type of the biomaterial or technique to be used. This experimental animal study aimed at comparing the effectiveness of two ridge preservation techniques.
Materials And Methods: Following the extraction of the distal roots of the mandibular second and fourth premolars of four dogs, the sockets were preserved using a combination of a collagen membrane intimately covering the socket plus a collagen matrix or a collagen membrane alone.
Objectives: To assess the impact of microgrooved abutments and the insertion depth on crestal bone changes at titanium implants with platform switch.
Materials And Methods: A total of n = 3 titanium implants (conical abutment connection) were inserted in each hemimandible of n = 6 foxhounds with the implant shoulder (IS) located at either epicrestal, supracrestal (+1 mm), or subcrestal (-1 mm) positions and randomly (split-mouth design) connected with machined or partially microgrooved healing abutments. At 20 weeks, tissue biopsies were processed for histological (primary outcome: net bone loss - NET) analyses.
Objectives: To histologically evaluate the effectiveness of a porcine derived collagen matrix (CM) and a subepithelial connective tissue graft (CTG) for coverage of localized gingival recessions.
Materials And Methods: Chronic single Miller Class I-like recessions were created at the buccal at the canines and at the third and fourth premolars in the upper and lower jaws of six beagle dogs. The defects were randomly treated with (1) coronally advanced flap surgery (CAF) + CM, (2) CAF + CTG, or (3) CAF alone.
Objectives: To evaluate the impact of plaque accumulation on osseointegration at surface enhanced modified hydrophilic titanium-zirconium (TiZr) alloy and titanium (Ti) implants.
Materials And Methods: TiZr and Ti implants with a sand-blasted, acid etched, and chemically modified endosseous and a machined (M) transmucosal portion were bilaterally (i.e.
Objectives: The present study was conducted to evaluate the bone tissue response after the application of an oily calcium hydroxide suspension (OCHS) into defects created in the tibial bone of minipigs.
Materials And Methods: Standardized defects (2 ccm) were created into the tibia of 4 Goettinger minipigs. Defects in the test group (n = 4) were filled with OCHS (Osteora, DFS-Diamon, Riedenburg, Germany).
Unlabelled: The soft tissues around dental implants are enlarged compared with the gingiva because of the longer junctional epithelium and the hemidesmosonal attachments are fewer, suggestive of a poorer quality attachment. Inflammatory infiltrates caused by bacterial colonization of the implant-abutment interface are thought to be one of the factors causing epithelial downgrowth and subsequent peri-implant bone loss. Gold alloys and dental ceramics as well as the contamination of the implant surface with amino alcohols, appear to promote epithelial downgrowth.
View Article and Find Full Text PDFObjectives: To histologically and immunologically assess experimental peri-implant mucositis at surface enhanced modified (mod) hydrophilic titanium implants.
Materials And Methods: In a split-mouth design (n = 6 foxhounds), four different implants were inserted on each side of the maxilla: three titanium-zirconium alloy implants (TiZr) with either modSLA (sand-blasted, acid etched and chemically mod), modMA (machined, acid etched and chemically mod), or M (machined) surfaces in the transmucosal portion, and one titanium implant with a machined transmucosal portion (TiM). Experimental mucositis was induced at one randomly assigned side (NPC), whereas the contra-lateral maxillary side received mechanical plaque removal three times per week (PC).
Objectives: This study seeks to assess and compare immunohistochemical characteristics of regenerated and pristine bone areas following surgical therapy of advanced peri-implantitis.
Methods: At ligature-induced peri-implantitis defects, the intrabony component was filled with a natural bone mineral (NBM), and the supracrestal component was treated by either an equine bone block (EB) or implantoplasty. NBM and EB were soak-loaded with rhBMP-2 or sterile saline.
Aims: The objective of this study is to evaluate the effects of a paste-like bone substitute material with easy handling properties and improved mechanical stability on periodontal regeneration of intrabony defects in dogs.
Materials And Methods: Mandibular and maxillary first and third premolars were extracted, and three-wall intrabony defects were created on second and fourth premolars. After a healing period of 3 months, acute type defects were filled with a paste-like formulation of deproteinized bovine bone mineral (DBBM) (particle size, 0.
Aim: The aim of the present study was to investigate the impact of proangiogenic factors [erythropoetin (EPO), human growth hormone (HGH), fibroblast growth factor (FGF), and platelet derived growth factor (PDGF-BB)] on the organization and biodegradation of a porcine-derived collagen matrix (CM) in rats.
Material And Methods: Collagen matrix specimens were soak-loaded either with EPO, HGH, FGF or PDGF-BB, each delivered in three concentrations (high, medium, low), and randomly allocated in unconnected subcutaneous pouches separated surgically on the back of 112 Wistar rats, which were divided into four groups (4, 7, 14 and 60 days of healing). Tissue biopsies were prepared for histological (e.
Objectives: To histologically evaluate and compare the performance of healing abutments with either hydrophobic or hydrophilic surface properties in humans.
Materials And Methods: According to a parallel-group design, titanium implants placed in the posterior mandible and maxilla of 30 patients were randomly assigned to either (1) hydrophobic machined (M), (2) chemically modified hydrophilic (mod) acid etched (MA) titanium (Ti) (modMA1) or (3) modMA Ti- Zirconium alloy (modMA2) healing abutments and left to heal in a transmucosal position. At 8 weeks, the abutments and a limited soft tissue biopsy were harvested according to a standardized procedure and processed for histological analysis (primary outcomes: percentage epithelial- (EC) and subepithelial connective tissue contact (CTC) to the abutment surface).
Objectives: This study aimed to immunohistochemically evaluate staged guided bone regeneration and osseointegration of titanium implants using two bone graft substitutes in combination with a polyethylene glycol (PEG) membrane in a dog model.
Materials And Methods: Saddle-type alveolar ridge defects were prepared in the lower jaws of 12 foxhounds and randomly filled with a natural bone mineral (NBM) or a biphasic calcium phosphate (SBC) and covered with an in situ gelling PEG membrane. After a healing period of 8 and 12 weeks (six animals each), modSLA titanium implants were inserted to heal in a submerged position.
Aim: The aim of the present study was to evaluate bone formation in vertical ridge augmentations using particulate bone grafting material stabilized by a resorbable polymer.
Material And Methods: Three vertical defects were created in the maxillary alveolar ridge of six Beagle dogs 3 months after the removal of all premolars. One defect in each dog was filled with tricalciumphosphate/hydroxylapatite (TCP/HA) grafting material and stabilized using a poloxamer hydrogel (test group).