Novel Dithiocarbamic Flavanones with Antioxidant Properties-A Structure-Activity Relationship Study.

The antioxidant properties of some 3-dithiocarbamic flavanones were investigated. Based on a previous study, we selected three frameworks that proved to be the most active ones. By varying the nature of the substituent at the para-position of flavanone ring , a structure-activity relationship study on radical scavenging activities was performed.

Novel Tricyclic Flavonoids as Promising Anti-MRSA Agents.

Methicillin-resistant (MRSA) is considered the main cause of nosocomial and community-associated infections. Because of antimicrobial resistance, MRSA infections are difficult or impossible to treat, leading to high mortality rates and significant economic and societal costs. In view of the MRSA challenge to public health all over the world, the identification of new and effective anti-MRSA agents is a high medical priority.

An Eco-Friendly Method to Synthesize Potent Antimicrobial Tricyclic Flavonoids.

The rapid emergence and spread of multidrug-resistant microorganisms is threatening our ability to treat common infections, with serious medical, social, and economic consequences. Despite substantial progress in the global fight against antibiotic resistance, the number of effective antibiotics is rapidly decreasing, underlying the urgent need to develop novel antimicrobials. In the present study, the green synthesis of novel iodine-substituted tricyclic flavonoids has been accomplished using an eco-friendly reagent, HPW-SiO, as a cyclization agent for the precursor 3-dithiocarmamic flavanones.

A Structure-Activity Relationship Study on the Antioxidant Properties of Dithiocarbamic Flavanones.

The antioxidant properties of 3-dithiocarbamic flavanones have been investigated. The influence of the halogen substituents on ring A of the flavanones and the nature of the secondary amine from the dithiocarbamic moiety have been accounted. The results indicated that the presence of a halogen substituent at the C-8 position of the benzopyran ring induce better antioxidant properties against DPPH and ABTS than butylated hydroxytoluene (BHT) and ascorbic acid.

Hydroxy Chalcones and Analogs with Chemopreventive Properties.

The aim of this review is to highlight the chemopreventive properties of hydroxy-substituted natural and synthetic chalcones along with a number of their analogs. These products display various biological activities, and have many applications against various diseases. Antioxidant and anti-inflammatory properties of chalcones bearing hydroxy substituents are underlined.

[2.2]Paracyclophane Derivatives as Building Blocks for Coordination Polymers.

Several new di- and tetracarboxylic [2.2]paracyclophane derivatives were obtained via Suzuki coupling between the appropriately brominated [2.2]paracyclophanes and 4-(methoxycarbonyl)phenylboronic acid.

Health Benefits of Key Constituents in L.

The genus () that originates from the Mediterranean area consists of six species (, , , , and ). L., commonly known as chicory, has a rich history of being known as a medicinal plant and coffee substitute.

An Improved Synthetic Method for Sensitive Iodine Containing Tricyclic Flavonoids.

The synthesis of new iodine containing synthetic tricyclic flavonoids is reported. Due to the sensitivity of the precursors to the heat and acidic conditions required for the ring closure of the 1,3-dithiolium core, a new cyclization method has been developed. It consists in the treatment of the corresponding iodine-substituted 3-dithiocarbamic flavonoids with a 1:1 (/) mixture of glacial acetic acid-concentrated sulfuric acid at 40 °C.

The influence of halogen substituents on the biological properties of sulfur-containing flavonoids.

A series of halogen-substituted tricyclic flavonoids containing a 1,3-dithiol-2-ylium moiety has been synthesized from the corresponding 3-dithiocarbamic flavanones. The influence of halogen substituents on the antibacterial properties of the tricyclic flavonoids has been investigated against Staphylococcus aureus and Escherichia coli. On going from fluorine to iodine, these compounds exhibit good to excellent inhibitory properties against both Gram-positive and Gram-negative pathogens.

Quantum chemical study of a derivative of 3-substituted dithiocarbamic flavanone.

The aim of this work is to characterize a quite novel 3-dithiocarbamic flavonoid by vibrational spectroscopy in conjunction with Density Functional Theory (DFT) calculations. Quantum mechanics calculations of energies, geometries and vibrational wavenumbers in the ground state were carried out by using hybrid functional B3LYP with 6-311G(d,p) as basis set. The results indicate a remarkable agreement between the calculated molecular geometries, as well as vibrational frequencies, and the corresponding experimental data.

Principal component analysis coupled with artificial neural networks--a combined technique classifying small molecular structures using a concatenated spectral database.

In this paper we present several expert systems that predict the class identity of the modeled compounds, based on a preprocessed spectral database. The expert systems were built using Artificial Neural Networks (ANN) and are designed to predict if an unknown compound has the toxicological activity of amphetamines (stimulant and hallucinogen), or whether it is a nonamphetamine. In attempts to circumvent the laws controlling drugs of abuse, new chemical structures are very frequently introduced on the black market.