Publications by authors named "Mihail Beliakov"
Article Synopsis
- Both peripheral neuropathy and depression associated with diabetes can result from sodium-calcium imbalance, prompting a study on the drug KB-R7943 as a potential treatment in a rat model.
- The pharmacokinetic study showed differences in drug exposure and distribution between diabetic rats and controls, with notable accumulation in the brain and heart, but lower penetration in diabetic rats.
- Chronic treatment with KB-R7943 demonstrated dose-dependent improvement in neuropathic and depression-like symptoms, indicating its potential for treating neurodegenerative effects of diabetes, although further safety studies are needed.
