The impact of warfarin on the rate of progression of aortic stiffness in hemodialysis patients: a longitudinal study.

Background: Accelerated progression of aortic stiffness in patients with advanced chronic kidney disease is not well explained by the traditional cardiovascular risk factors. We hypothesized that vitamin K deficiency may result in an accelerated progression of aortic stiffness in the pro-calcifying uremic milieu.

Method: Eighteen hemodialysis (HD) patients on warfarin were matched to 54 HD patients without warfarin (control).

Impact of dialysate calcium concentration on the progression of aortic stiffness in patients on haemodialysis.

Background: Higher dialysate calcium (DCa) can result in an acute and transient increase in arterial stiffness. The aim of the present study is to evaluate the impact of DCa on the progression of arterial stiffness, calcium balance and bone metabolism in haemodialysis (HD) patients over a 6-month period. Method.

Effects of acute variation of dialysate calcium concentrations on arterial stiffness and aortic pressure waveform.

Background: Abnormal mineral metabolism in chronic kidney disease plays a critical role in vascular calcification and arterial stiffness. The impact of presently used dialysis calcium concentration (D(Ca)) on arterial stiffness and aortic pressure waveform has never been studied. The aim of the present study is to evaluate, in haemodialysis (HD) patients, the impact of acute modification of D(Ca) on arterial stiffness and central pulse wave profile (cPWP).