Publications by authors named "Mihai Palade"
Aflatoxin B1 (AFB1) is a mycotoxin that frequently contaminates cereals and cereal byproducts. This study investigates the effect of AFB1 on the mesenteric lymph nodes (MLNs) of piglets and evaluates if a diet containing grape seed meal (GSM) can counteract the negative effect of AFB1 on inflammation and oxidative stress. Twenty-four weaned piglets were fed the following diets: Control, AFB1 group (320 μg AFB1/kg feed), GSM group (8% GSM), and AFB1 + GSM group (8% GSM + 320 μg AFB1/kg feed) for 30 days.
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- The study aimed to evaluate how grape seed byproduct could help reduce the negative effects of aflatoxin B1 (AFB1) on the health of weaned piglets, particularly concerning their plasma, liver, and gastrointestinal tract.
- Twenty-four crossbred pigs were divided into four diet groups: a control, an AFB1-contaminated feed, a grape seed meal diet, and a combination of AFB1 and grape seed feed, over a period of 30 days.
- Results indicated that AFB1 caused significant health issues, but adding grape seed meal improved the pigs’ antioxidant enzyme activity, reduced inflammation, and ultimately enhanced growth performance despite the presence of AFB1.
Article Synopsis
- Ochratoxin A (OTA) is a harmful compound produced by certain fungi, primarily affecting organs like the kidneys and gut.
- The study examined the effects of a 30-day exposure to low doses of OTA in young pigs, looking at their immune responses and oxidative stress levels.
- Findings revealed that even low levels of OTA significantly impacted immune functionality and antioxidant defenses, with more pronounced effects observed in the intestine compared to the kidneys.
Article Synopsis
- Ochratoxin A (OTA), a mycotoxin from fungi like Aspergillus and Penicillium, was tested in a study on its effects on piglets fed a diet contaminated with low levels of OTA (0.05 mg/kg).
- After 30 days, the study found significantly higher levels of OTA in the kidney of poisoned piglets, along with changes in around 105 different genes related to immune response and cellular functions.
- Although OTA did not affect certain kidney functions like urea and creatinine levels, the findings suggest potential early carcinogenic effects and immune response activation that warrant further research regarding implications for human health.