Publications by authors named "Mihai Adrian Constantinescu"
Article Synopsis
- Seroma formation is a common issue after surgeries, but current treatments are not effective.
- A new study tested a nano-bridging technique in rats to see if it could reduce seroma formation after surgical procedures.
- Results showed that the nanoparticle treatment led to complete remission of seromas, while traditional fibrin glue only partially reduced fluid volume, suggesting nanoparticles could be a promising solution for treating seromas without adverse side effects.
Article Synopsis
- The study investigates the impact of increasing blood flow in a perforator flap on its survival, aiming to reduce the occurrence of flap necrosis commonly faced in reconstructive surgery.
- In an experiment with 30 male Lewis rats, three groups were tested: a control group, a group with acute inflow, and a group with arterial preconditioning, with results measured on flap survival and blood flow post-surgery.
- The findings revealed that the group with acute inflow had the highest flap survival rate and improved blood flow in specific areas, indicating that optimizing arterial inflow can enhance the survival of perforator flaps.
A quantitative analysis of microcirculation in sore-prone pressure areas on conventional and pressure relief hospital mattresses using laser Doppler flowmetry and tissue spectrophotometry.
J Tissue Viability
November 2014
Background: Pressure ulcers are associated with severe impairment for the patients and high economic load. With this study we wanted to gain more insight to the skin perfusion dynamics due to external loading. Furthermore, we evaluated the effect of different types of pressure relief mattresses.
View Article and Find Full Text PDFBackground: Recently performed vascularized composite tissue allotransplantations (CTAs) stimulate the ongoing research in the area of whole-limb transplantation. A reliable in vivo animal model is required for investigations in vascularized whole-limb CTA. The model should allow in vivo assessment in whole-limb preservation, allograft and xenograft response, and host immunomodulation.
View Article and Find Full Text PDFBackground: Recent literature demonstrates hyperglycemia to be common in patients with trauma and associated with poor outcome in patients with traumatic brain injury and critically ill patients. The goal of this study was to analyze the impact of admission blood glucose on the outcome of surviving patients with multiple injuries.
Methods: Patients' charts (age >16) admitted to the emergency room of the University Hospital of Berne, Switzerland, between January 1, 2002, and December 31, 2004, with an Injury Severity Score >or=17 and more than one severely injured organ system were reviewed retrospectively.
Purpose: The goal of this study was to analyse a possible association of admission blood glucose with hospital mortality of polytraumatised patients and to develop an outcome prediction model for this patient group.
Methods: The outcome of adult polytraumatised patients admitted to the University Hospital of Berne, Switzerland, between 2002 and 2004 with an ISS > or = 17, and more than one severely injured organ system was retrospectively analysed.
Results: The inclusion criteria were met by 555 patients, of which 108 (19.