Publications by authors named "Mihaela Ostan"

Background: The inclusion of synthetic amino acids in poultry nutrition plays a crucial role in both enhancing the synthesis of immunoglobulins and elevating the overall comprehensiveness of the amino acid profile.

Objectives: This research examined the effects of consuming threonine (Thr) in various forms levels with low or high oil on broiler chickens' growth and immunity.

Methods: We investigate the growth performance, feed efficiency, immune response, intestinal morphology, absorptive capacity, and expression of some genes related to the feed intake (Pro-opiomelanocortin [POMC]), fatty acid synthesis (Acetyl-CoA Carboxylase [ACC]), immunity (lipopolysaccharide-induced tumour necrosis like alpha factor [LITAF]), and heat shock protein 70 (HSP70).

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The major contribution of myocardial damage to global mortalities raises debate regarding the exploration of new therapeutic strategies for its treatment. Therefore, our study investigated the counteracting effect of tiron against isoprenaline (ISO)-mediated cardiac infarction in mice. Tiron was administered to mice for 7 days prior to two consecutive injections of ISO on days 8 and 9 of the treatment protocol.

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Article Synopsis
  • Acetaminophen (APAP) is known to cause acute liver damage, and this study investigates the potential protective effects of empagliflozin (EMPA) against APAP-induced toxicity in mice.
  • The research involved analyzing various biomarkers and proteins related to liver function and inflammation, revealing that APAP treatment led to significant liver impairment, characterized by increased oxidative stress and mitochondrial dysfunction.
  • EMPA was found to alleviate these harmful effects, restoring liver function, promoting mitochondrial health, and reducing inflammation, suggesting its potential as a therapeutic agent against liver damage from APAP.
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Background: Buffalo spermatozoa have a distinct membrane structure that makes them more vulnerable to cryopreservation, resulting in lower-quality post-thawed sperm. This decreases the success rate of artificial insemination in buffaloes. Understanding and addressing these specific vulnerabilities are essential for improving reproductive techniques in buffalo populations.

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Biosynthetic metals have attracted global attention because of their safety, affordability, and environmental friendliness. As a consequence, the cell-free filtrate (CFF) of Dill leaf-derived endophytic fungus was employed for the extracellularly synthesis silver nanoparticles (AgNPs). A reddish-brown color shift confirmed that AgNPs were successfully produced.

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Nano carriers have gained more attention for their possible medical and technological applications. Tailored nanomaterials can transport medications efficiently to targeted areas and allow for sustained medication discharge, reducing undesirable toxicities while boosting curative effectiveness. Nonetheless, transitioning nanomedicines from experimental to therapeutic applications has proven difficult, so different pharmaceutical incorporation approaches in nano scaffolds are discussed.

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  • * The study investigated the protective effects of ChV on AFT-induced kidney damage and egg quality in quails, finding that AFT exposure led to kidney injury and decreased egg quality due to increased oxidative stress and inflammatory responses.
  • * ChV supplementation improved kidney health and egg quality by reducing AFT-related oxidative stress and inflammation, suggesting that dietary inclusion of ChV could be a viable approach to mitigate the negative effects of AFT.
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The immunological genes that may interact with inflammatory postpartum diseases in Italian buffaloes were examined in this study. A total number of 120 female Italian buffaloes (60 normal and 60 with inflammatory reproductive diseases) were employed. Each buffalo's jugular vein was pierced to get five milliliters of blood.

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