Publications by authors named "Mihaela Golic"

Background: Lithium is an essential psychopharmaceutical, yet side effects and concerns about severe renal function impairment limit its usage.

Aims: Our objectives were to quantify the occurrence of chronic kidney disease stage 4 or higher (CKD4 +) within a lithium-treated population, using age- and time-specific cumulative incidence and age-specific lifetime risk as measures of disease occurrence. Additionally, we aimed to investigate the association between the duration of lithium treatment and the risk of CKD4 + .

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Background: Modern lithium management guidelines were introduced to improve the renal prognosis of lithium patients.

Aims: To examine whether prospects for severe renal impairment (defined as chronic kidney disease at least stage 4 (CKD4)), in long-term lithium patients, have changed over time after the introduction of lithium monitoring guidelines.

Methods: The time to and hazard for CKD4 were compared between three patient cohorts who started long-term lithium in three consecutive decades: 1980s, 1990s and 2000s.

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Background: Little is known of the risks involved for patients who, at the start of lithium treatment, already have compromised renal function.

Aims: To assess the risk of developing severe renal impairment (chronic kidney disease (CKD) 4-5) among those patients and to explore predictors for the progression.

Methods: A retrospective longitudinal cohort study using data from Sahlgrenska University Hospital's laboratory database 1981-2017.

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Article Synopsis
  • The study reviewed long-term lithium treatment compliance with Swedish guidelines from 1981 to 2010, analyzing data from over 2800 patients and 25,300 treatment-years.
  • Compliance with monitoring guidelines improved from 36% in 1981 to 68% in 2010, with women showing slightly better adherence than men.
  • Serum lithium levels mostly stayed within recommended ranges, with a steady decrease from 0.70 mmol/L in 1981 to 0.58 mmol/L in 2001, but remained stable after that point.
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