Publications by authors named "Mihaela Ghita-Pettigrew"
Article Synopsis
- Radiotherapy (RT) is crucial for treating non-small cell lung cancer (NSCLC), but local recurrence remains a challenge, particularly in late-stage patients with PTEN loss contributing to increased radio-resistance.
- This study investigated the effectiveness of combining RT with the ATR inhibitor Ceralasertib in PTEN-depleted NSCLC cells, using both in vitro and in vivo models, which showed significant tumor growth inhibition and delayed DNA repair.
- The results indicated that this combination selectively sensitizes PTEN-depleted NSCLC without causing early inflammatory responses typically associated with radiation pneumonitis, supporting further investigation of ATR inhibition alongside RT for patients with PTEN mutations.
Background And Purpose: Radiation induced cardiotoxicity (RICT) is as an important sequela of radiotherapy to the thorax for patients. In this study, we aim to investigate the dose and fractionation response of RICT. We propose global longitudinal strain (GLS) as an early indicator of RICT and investigate myocardial deformation following irradiation.
View Article and Find Full Text PDFBackground And Purpose: Radiomics is a rapidly evolving area of research that uses medical images to develop prognostic and predictive imaging biomarkers. In this study, we aimed to identify radiomics features correlated with longitudinal biomarkers in preclinical models of acute inflammatory and late fibrotic phenotypes following irradiation.
Materials And Methods: Female C3H/HeN and C57BL6 mice were irradiated with 20 Gy targeting the upper lobe of the right lung under cone-beam computed tomography (CBCT) image-guidance.