Publications by authors named "Mihaela Eugenia Dinca"
Association between genetic variants and depression in a Romanian cohort.
Rom J Morphol Embryol
January 2022
Article Synopsis
- * The research involved 82 Romanian patients with MDD and 286 healthy controls, focusing on two genetic variants (NR3C1 rs41423247 and BDNF rs6265) using PCR techniques.
- * Although the study found specific minor allele frequencies in the Romanian cohort, the genetic variants did not show significant associations with MDD, highlighting potential inconsistencies in previous literature and issues with the study’s sample size.
Depression is a significant contributor to the overall burden of disease on a global scale. Thyroid hormones thyroxine (T4) and triiodothyronine (T3) have been shown to play a critical role in the development and normal function of the brain. It has been suggested that dysregulation of thyroid function could be associated with depression, especially hypothyroidism, but not all studies support this hypothesis.
View Article and Find Full Text PDFIt has long been suspected that the hypothalamic pituitary adrenal (HPA) axis plays a role in the pathophysiology of depression. Whether this association exists or not, and if it does, the degree of its significance, remain highly disputed. The issue is further complicated as no consensus currently exists on cortisol sampling timepoints or methods.
View Article and Find Full Text PDF