Publications by authors named "Miguel Zambrano-Lucio"
Despite uncertainty about the specific molecular mechanisms driving major depressive disorder (MDD), the Wnt signaling pathway stands out as a potentially influential factor in the pathogenesis of MDD. Known for its role in intercellular communication, cell proliferation, and fate, Wnt signaling has been implicated in diverse biological phenomena associated with MDD, spanning neurodevelopmental to neurodegenerative processes. In this systematic review, we summarize the functional differences in protein and gene expression of the Wnt signaling pathway, and targeted genetic association studies, to provide an integrated synthesis of available human data examining Wnt signaling in MDD.
View Article and Find Full Text PDFThe gastrointestinal (GI) system is affected in Alzheimer's disease (AD); however, it is currently unknown whether GI alterations arise as a consequence of central nervous system (CNS) pathology or play a causal role in the pathogenesis. GI mucus is a possible mediator of GI dyshomeostasis in neurological disorders as the CNS controls mucus production and secretion via the efferent arm of the brain-gut axis. The aim was to use a brain-first model of sporadic AD induced by intracerebroventricular streptozotocin (STZ-icv; 3 mg/kg) to dissect the efferent (i.
View Article and Find Full Text PDFIntroduction: There exists clinical interest in the following question: Is there an association between HOMA-IR and the risk of developing metabolic diseases?
Aims: Assessing the association between high values of HOMA-IR with the incidence of T2DM, MACE, essential hypertension, dyslipidemia, NASH, and cancer in healthy participants and participants with a component of metabolic syndrome.
Methods: Databases were searched by an experienced librarian to find eligible studies. Observational cohort studies enrolling healthy adults and adults with metabolic syndrome components that evaluated HOMA as a marker of IR were considered for inclusion.
Article Synopsis
- Phaeohyphomycosis is a serious infection caused by pigmented fungi, particularly affecting immunocompromised children, with a lower mortality rate compared to adults (22.3% in children vs. 79% in adults).
- A review of 130 pediatric cases showed common risk factors like hematologic malignancies, neutropenia, and steroid therapy, with localized infections being the most prevalent type (61.5%).
- Most cases were treated successfully with antifungal therapy (87%), but the mortality rate varied significantly based on the infection site and patient conditions, indicating a need for more research.
Article Synopsis
- * Among the 496 articles analyzed, the majority were observational studies, with government funding being the primary source (60%), followed by industry (23.83%) and non-governmental organizations (16.06%).
- * Although industry funding showed a slight declining trend, no significant link was found between funding sources and positive study outcomes that supported authors' hypotheses.