Publications by authors named "Miguel Rodriguez-Fernandez"
Role of rectal colonization by third-generation cephalosporin-resistant Enterobacterales on the risk of surgical site infection after hepato-pancreato-biliary surgery.
Microbiol Spectr
November 2024
Unlabelled: The impact of third-generation cephalosporin-resistant Enterobacterales (3GCR-E) rectal colonization in the development of subsequent infection after surgery is controversial. In particular, there is a lack of data in the context of hepato-pancreato-biliary (HPB) surgery. The objective of this study was to assess the prevalence of 3GCR-E intestinal carriage among patients undergoing elective HPB resection surgery and its impact on the incidence and etiology of surgical site infections (SSIs).
View Article and Find Full Text PDFMaternal COVID-19 Serological Changes-Comparison between Seroconversion Rate in First and Third Trimesters of Pregnancy and Subsequent Obstetric Complications: A Cohort Study.
Viruses
December 2023
Article Synopsis
- Pregnant women are more susceptible to respiratory diseases, prompting a study on SARS-CoV-2 seroconversion rates during different pregnancy trimesters.
- The observational cohort study, conducted during the early COVID-19 pandemic in Madrid, included 470 women who underwent routine blood tests in their first and third trimesters.
- Results showed higher seroconversion in the third trimester (14.0%) compared to the first (6.6%), but no significant differences in maternal or obstetric complications between those who seroconverted earlier or later in pregnancy.
Article Synopsis
- - The study investigated the usefulness of the cerebroplacental ratio (CPR) in predicting adverse outcomes in low-risk pregnancies during routine prenatal care at 40-42 weeks in Spain and the UK from 2017 to 2019.
- - Researchers analyzed 3,143 singleton pregnancies and found 17.1% had adverse outcomes; factors like maternal age and BMI were significant predictors, but adding CPR to the predictive model didn't improve accuracy.
- - Ultimately, the CPR showed a low detection rate (11.9%) for adverse outcomes, indicating it is not an effective predictor in late-term uncomplicated pregnancies.
Clinical case of a patient with a multidrug-resistant prosthetic vascular graft infection which was treated with a cocktail of phages (PT07, 14/01, and PNM) in combination with ceftazidime-avibactam (CZA). After the application of the phage treatment and in absence of antimicrobial therapy, a new bloodstream infection (BSI) with a septic residual limb metastasis occurred, now involving a wild-type strain being susceptible to ß-lactams and quinolones. Clinical strains were analyzed by microbiology and whole genome sequencing techniques.
View Article and Find Full Text PDFObjectives: To investigate the role of previous antibiotic therapy in the risk of recurrence after a infection (CDI) treated with vancomycin.
Methods: Multicentre observational study. Patients with a CDI episode achieving clinical cure with oral vancomycin and followed up 8 weeks were included.
Objective: To investigate the impact of COVID19 pandemic on the incidence of health-care associated Clostridioides difficile infection (HA-CDI).
Methods: Retrospective study conducted in the Hospital Universitario de Valme (HUV) and the Hospital General Universitario de Alicante (HGUA) in Spain between January 2019 and February 2021. The study period was divided into non-COVID19 period (2019 and months from 2020 to 2021 with ≤30 hospitalized COVID19 patients) and COVID19 period (months from 2020 to 2021 with >30 COVID19 patients).
Background: The aim of this study was to describe the natural history of acute Q fever, including its clinical and serological evolution and progression to chronic Q fever.
Methods: Observational cohort study (January 2011-September 2020) performed at Valme University Hospital (Seville, Spain). Inclusion criteria: (1) patients aged ≥18 years; (2) acute Q fever diagnosis, defined as suggestive symptoms in the presence of phase II immunoglobulin G (IgG) titer >1:256; (3) at least 6 months' follow-up after the acute Q fever episode.
Background: Previous studies have suggested that hepatocellular carcinoma (HCC) has an aggressive presentation and a shorter survival in people with HIV (PWH). This could be due to later diagnosis or lower rates of HCC treatment, and not to HIV infection itself. AIM: :: To assess the impact of HIV on HCC survival in hepatitis C virus (HCV)-infected patients.
View Article and Find Full Text PDFObjective: To assess the performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma (HCC) in HIV-infected patients.
Methods: The GEHEP-002 cohort recruits HCC cases diagnosed in HIV-infected patients from 32 centers across Spain. The proportion of 'ultrasound lack of detection', defined as HCC diagnosed within the first 3 months after a normal surveillance ultrasound, and the proportion of 'surveillance failure', defined as cases in which surveillance failed to detect HCC at early stage, were assessed.