Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses.

Background: The cytokine interleukin-25 (IL-25) is recognized as the most relevant initiator of protective T helper 2 (Th2) responses in intestinal helminth infections. This cytokine induces resistance against several species of intestinal helminths, including the trematode Echinostoma caproni. E.