Histologically benign metastatic meningioma: morphological and cytogenetic study. Case report.

The authors report on a 75-year-old man with histologically benign fibroblastic meningioma metastasizing to the lung, liver, spleen, and kidney. The original tumor exhibited a complex karyotype involving different structural and numerical anomalies associated with monosomy of chromosome 22. The implication of chromosome 1p36 was confirmed by fluorescence in situ hybridization in most interphase nuclei.

[Monosomy 1p and alkaline phosphatase in meningiomas. Citopathological, histochemical and genetical study in 10 tumors].

Background: Cytogenetic studies in meningiomas show that 1p monosomy constitutes an important factor involved in their progression. Genes coding for unspecific alkaline phosphatase (AP-un) are located in this chromosome, in particular in 1p34-p36.1.