Publications by authors named "Miguel Marquez-Gutierrez"
Article Synopsis
- Autoimmune lymphoproliferative syndrome (ALPS) is a rare immune disorder caused by defects in the lymphocyte apoptotic pathway, leading to misdiagnosis challenges.
- The study focused on two children with suspected ALPS, analyzing their blood cells and sequencing relevant genes for mutations linked to the disorder.
- Key findings included a significant mutation in one patient that caused protein truncation, while proteomic analysis in the other revealed altered levels of proteins related to cell cycle regulation and immune response, potentially explaining the disease's impact.
Background: Cervical cancer is highly associated with human papillomavirus (HPV) E6 and E7 gene expression. We have previously reported two antisense oligodeoxynucleotides (AS-ODNs) directed against adjacent targets within the HPV-16 E6/E7 mRNA (419 and 434), each able to downregulate HPV-16 E6/E7 mRNA in vitro and in vivo and to specifically inhibit tumor cell growth in culture and animal models.
Methods: Towards potential clinical application and improved in vivo performance, we analyzed the effect of the combined treatment of 419-434 AS-ODNs on the anchorage independent growth (AIG) of HPV-16-positive cervical carcinoma cell lines.