Publications by authors named "Miguel Mansilla Polo"
Guselkumab, Risankizumab, and Tildrakizumab demonstrate parallel effectiveness and safety in psoriasis treatment: a head-to-head comparative study in real clinical practice.
An Bras Dermatol
August 2024
Biologics Versus JAK Inhibitors. Part II: Risk of Infections. A Narrative Review.
Dermatol Ther (Heidelb)
August 2024
Article Synopsis
- The study reviews infection risks associated with biological drugs (BD) and Janus kinase inhibitors (JAKi) specifically in dermatology, noting that while the overall infection rates are low, they remain higher than the general population.
- It highlights that certain JAKi and anti-TNF agents, particularly tofacitinib, have a greater association with infection risks, including specific infections like tuberculosis and candidiasis.
- The analysis suggests careful monitoring for patients on these treatments and calls for more long-term studies to better understand these risks.
Hematopoietic stem cell transplantation (HSCT) has improved outcomes for severe hematologic, malignant, and immune disorders, yet poses an increased risk of subsequent malignancies. This study aimed to examine the risk of skin cancer following HSCT and identify potential risk factors. The search was conducted in MEDLINE, EMBASE, and CINAHL databases until December 2023.
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- The research evaluates the effectiveness and safety of bimekizumab for treating hidradenitis suppurativa in real-world clinical settings.
- Significant improvements were observed in key activity scores and patient-reported outcomes after 16 weeks, with all results showing a strong statistical significance (p < 0.001).
- Bimekizumab was well-tolerated with no reported discontinuations or new safety issues, reaffirming its favorable safety profile previously seen in phase 3 clinical trials.
Mpox Pharyngitis.
Indian J Otolaryngol Head Neck Surg
June 2024
A case of mpox pharyngitis in absence of cutaneous lesions is reported. Usually, clinical presentation is either a cutaneous eruption or a combination of cutaneous and mucosal lesions. In patients with atypical pharyngitis, regardless of the presence of skin lesions, pharyngeal swabs should be collected to rule out mpox.
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- - A 14-month-old child was diagnosed with Staphylococcal Scalded Skin Syndrome (SSSS), characterized by widespread skin redness, pain, and crusting around the mouth, leading to hospitalization.
- - SSSS primarily affects children and is caused by certain strains of Staphylococcus aureus that release exfoliative toxins, leading to skin blisters typically within 48 hours.
- - Diagnosis is based on clinical evaluation, and treatment typically involves intravenous antibiotics like cloxacillin and electrolyte replacement to manage the condition.
Biologics Versus JAK Inhibitors. Part I: Cancer Risk. A Narrative Review.
Dermatol Ther (Heidelb)
June 2024
Introduction: Biological drugs (BD) and Janus kinase inhibitors (JAKi) have revolutionized the treatment of diverse dermatoses. However, there are concerns regarding their safety, especially the risk of cancer and opportunistic infections. Here, we discuss the risk of cancer associated with the BD and JAKi used in dermatology.
View Article and Find Full Text PDFBackground: Certolizumab is an Fc-free PEGylated tumor necrosis factor-alpha (TNFα) inhibitor recently approved for the treatment of moderate-to-severe plaque psoriasis, although there is limited real-world evidence on the effectiveness and safety in patients with plaque psoriasis treated with certolizumab. The objective of this article is to determine the effectiveness, drug survival, and safety, including pregnancy, childbirth, and lactation, of certolizumab in moderate-to-severe plaque psoriasis under real-world conditions.
Methods: This is a retrospective, multicenter, observational study performed in 15 hospitals in Spain.