Assessing vocabulary acquisition using a fast-mapping task in an Android application: A pilot study.

Purpose: The aim of this study was to explore whether a fast mapping task embedded in an Android application (FastMApp) is a valid tool to assess referent selection abilities in Spanish-speaking children aged between 18 and 30 months. Traditional assessment tools for lexical development use static quantitative methods that assign children a final score to represent their overall vocabulary level. These methods fail to provide insights into the learning process, despite their potential relevance for clinical and educational purposes.

Mind the suffix: Pseudoword processing in children and adults.

Previous evidence has shown that pseudowords made up of real morphemes take more time to process and generate more errors than pseudowords without morphemes in a lexical decision task. The explanation for these results is controversial because two possible arguments may be posited; the first is related to the morphological composition of the stimuli, and the second is related to the larger semantic interpretability of pseudowords with morphemes in comparison with pseudowords without morphemes (a semantic-based explanation). To disentangle this issue, we conducted an experiment with 92 children and 42 adults.

Transposition and substitution-letter effects in a flanker task: Evidence from children and adults.

Several studies have shown that parafoveal processing is essential in reading development. In this study, we explore the effect of transposing and substituting inner and outer letters in a flanker lexical decision task administered to 78 children and 65 adults. The results show a significant interaction between the Group factor and the Flanker factor, suggesting differences in the effects of flankers for children and adults.

"I don't know who you are": anomia for people's names in Alzheimer's disease.

It is well known that difficulty in the retrieval of people's names is an early symptom of Alzheimer's Disease Dementia (ADD), but there is a controversy about the nature of this deficit. In this study, we analyzed whether the nature of the difficulty in retrieving proper names in ADD reflects pre-semantic, semantic, or post-semantic difficulties. To do so, 85 older adults, 35 with ADD and 50 cognitively healthy (CH), completed a task with famous faces involving: recognition, naming, semantic questions, and naming with phonological cues.

[The effect of the pandemic on language development in the first two years of life].

Background And Objectives: The effects that the COVID-19 pandemic may have had on the language development of children are still poorly understood. In this study, we examine the effect of the pandemic on this development by analyzing the vocabulary and the morphosyntactic level in a sample of toddlers.

Participants And Method: One hundred and fifty-three boys and girls between 18 and 31 months of age participated in the study.

The Effect of Semantic Transparency in a Flanker Task.

This study tried to replicate and extend the semantic transparency morphological effect using the flanker lexical decision paradigm (Grainger et al., 2020). In the first experiment, stems were used as flankers of target words that could be truly morphological (), pseudomorphological (), or form-related with the flanker ().

Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection.

Background: Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. Novel approximations are trying to treat these patients with gene therapy, namely, using viral vectors.

Sentence Repetition Tasks to Detect and Prevent Language Difficulties: A Scoping Review.

Sentence repetition tasks (SRTs) have been widely used in language development research for decades. In recent years, there has been increasing interest in studying performance in SRTs as a clinical marker for language impairment. What are the characteristics of SRTs? For what purposes have SRTs been used? To what extent have they been used with young children, in different languages, and with different clinical populations? In order to answer these and other questions, we conducted a scoping review.

Morpho-orthographic segmentation of opaque and transparent derived words: New evidence for Spanish.

Semantic transparency has been extensively analysed in research on visual word recognition. Under the masked priming paradigm, it has consistently been shown that opaque and transparent words are facilitated relative to form-related controls, but differences in priming between one condition and another have not been conclusively proven. Hence, research has been unable to theoretically elucidate the possible value of semantic transparency in the processing of derived words.

A Sentence Repetition Task for Early Language Assessment in Spanish.

Sentence repetition tasks have been widely used in the last years as a diagnostic tool in developmental language disorders. However in Spanish there are few (if any) of these instruments, especially for younger children. In this context, we develop a new Sentence Repetition Task for assessing language (morphosyntactic) abilities of very young Spanish children.

Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: Boosting the efficacy of intravenously administered therapeutic adenoviruses.

Oncolytic adenoviruses are used as agents for the treatment of cancer. However, their potential is limited due to the high seroprevalence of anti-adenovirus neutralizing antibodies (nAbs) within the population and the rapid liver sequestration when systemically administered. To overcome these challenges, we explored using nanoparticle formulation to boost the efficacy of systemic oncolytic adenovirus administration.

Perceptual salience of derivational suffixes in visual word recognition.

This study analyzes the role of derivational suffixes in visual word recognition, tracking the eye movements of 31 participants in a sentence-reading task in Spanish. Perceptual salience of suffixes was operationalized as the proportion of letters represented by the suffixes with respect to the full words, that is, we relate the number of letters comprising the suffixes to the number of letters in the words in which they appear. The results reveal a significant role in first fixation duration of both word frequency - the more frequent the word, the shorter the fixations, and perceptual salience - the more salient the suffix, the longer the fixations.

In Vivo Retargeting of Poly(beta aminoester) (OM-PBAE) Nanoparticles is Influenced by Protein Corona.

One of the main bottlenecks in the translation of nanomedicines from research to clinics is the difficulty in designing nanoparticles actively vectorized to the target tissue, a key parameter to ensure efficacy and safety. In this group, a library of poly(beta aminoester) polymers is developed, and it is demonstrated that adding specific combinations of terminal oligopeptides (OM-PBAE), in vitro transfection is cell selective. The current study aims to actively direct the nanoparticles to the liver by the addition of a targeting molecule.

An in-vitro study to evaluate high-volume low-pressure endotracheal tube cuff deflation dynamics.

Background: High-volume low-pressure (HVLP) endotracheal tube (ETT) cuffs for critically ill patients often deflate during the course of mechanical ventilation. We performed an in-vitro study to comprehensively assess HVLP cuff deflation dynamics and potential preventive measures.

Methods: We evaluated 24-hour deflation of seven HVLP cuffs of cylindrical or tapered shape, and made of polyvinylchloride or polyurethane.

Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas.

Glioblastoma multiforme (GBM) is the most devastating primary brain tumor due to its infiltrating and diffuse growth characteristics, a situation compounded by the lack of effective treatments. Currently, many efforts are being devoted to find novel formulations to treat this disease, specifically in the nanomedicine field. However, due to the lack of comprehensive characterization that leads to insufficient data on reproducibility, only a reduced number of nanomedicines have reached clinical phases.

Word and Nonword Repetition Abilities in Spanish Language: Longitudinal Evidence from Typically Developing and Late Talking Children.

This longitudinal study examined the early word and nonword repetition abilities of monolingual Spanish speaking children. We explored the role that word status, word length, and time play in repetition performance of children with different vocabulary levels. We also examined the predictive value of vocabulary level in repetition abilities.

Written Type and Token Frequency Measures of Fifty Spanish Derivational Morphemes.

Several databases of written language exist in Spanish that manage important information on the lexical and sublexical characteristics of words. However, there is no database with information on the productivity and frequency of use of derivational suffixes: sublexical units with an essential role in the formation of orthographic representations and lexical access. This work examines these two measures, known as type and token frequencies, for a series of 50 derivational suffixes and their corresponding orthographic endings.

How orthographic transparency affects morphological processing in young readers with and without reading disability.

This study investigates how orthographic modifications to the stems of complex words affect morphological processing in proficient young Spanish readers and children with reading deficits. In a definition task all children, irrespective of their reading skill, were worse at defining derived words that had an orthographic alteration of the base stem than words with no orthographic alteration. In a go/no-go lexical decision task, an interaction between base frequency and orthographic alteration was found: base frequency affected derived words with no orthographic alteration more than words with alterations, irrespective of reading skill.

The suffix priming effect: Further evidence for an early morpho-orthographic segmentation process independent of its semantic content.

This work presents the results of a masked lexical decision experiment in which we explore the morphological parsing of Spanish suffixed or pseudosuffixed words through the suffix priming effect. Priming the bases or pseudobases with their suffixed or pseudosuffixed forms is the standard process in experiments aimed at understanding the processes underlying morphological parsing in visual word recognition with masked priming lexical decision (e.g.

Morphological processing in reading disabled and skilled Spanish children.

This article presents the results of a lexical decision experiment in which the base frequency (BF) effect is explored in reading disabled children and skilled readers. Three groups of participants were created. The first group was composed of children with reading disorders, the second group of skilled readers matched with the first group for chronological age and the third group of skilled readers matched for vocabulary size.

Differences on morphological and phonological processing between typically developing children and children with Down syndrome.

It is widely acknowledged that people with Down syndrome (Ds) have less highly developed morphosyntactic abilities than typically developing (TD) children. However, little is known about the morphological processing of this population. In this paper we carry out two experiments in which the morphological Base Frequency (BF) effect is explored in both groups.

A study of base frequency in Spanish skilled and reading-disabled children: all children benefit from morphological processing in defining complex pseudowords.

In this study, the base frequency (BF) effect is explored in reading-disabled and skilled readers of Spanish. A pseudoword definition task was completed by two groups of children. The pseudowords were composed from existing stems and affixes.

The effect of family size on spanish simple and complex words.

This study presents the results of three experiments in which the Family Size (FS) effect is explored. The first experiment is carried out with no prime on simple words. The second and third experiments are carried out with morphological priming on complex words.

Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis.

Follicular dendritic cell sarcoma (FDCS) is a very rare malignant tumor arising most frequently in lymph nodes with only few reports of extranodal locations. We report the case of a 35-year-old man with a large retroperitoneal mass. Histologically the tumor was composed of highly pleomorphic cells exhibiting some uncommon features such as an epithelioid appearance, cystic spaces, and multinucleated cells with morphologic features of emperipolesis.

Dynamics of the IncW genetic backbone imply general trends in conjugative plasmid evolution.

Plasmids cannot be understood as mere tools for genetic exchange: they are themselves subject to the forces of evolution. Their genomic and phylogenetic features have been less studied in this respect. Focusing on the IncW incompatibility group, which includes the smallest known conjugative plasmids, we attempt to unveil some common trends in plasmid evolution.