Publications by authors named "Miguel Herreros-Martinez"
Article Synopsis
- There is a shared relationship between cardiovascular disease (CVD) and cancer, tied to common risk factors and biological pathways, which the study aims to explore across three diverse ethnic cohorts.
- The researchers employed a two-stage methodology involving epigenome-wide association studies and targeted analysis of differentially methylated positions (DMPs), unveiling significant epigenetic markers for CVD and cancer.
- The findings indicate interconnected biological pathways for CVD and cancer, suggesting potential for precision prevention strategies, including screening based on epigenetic signatures to identify at-risk patients in early diagnosis stages.
Article Synopsis
- Liver cancer rates have increased among American Indians/Alaska Natives, and blood DNA methylation could serve as a potential biomarker for cancer risk.
- The study analyzed DNA from 2,324 participants aged 45-75 from various states, tracking liver cancer deaths over a follow-up period averaging 25 years.
- Nine specific DNA methylation sites were linked to liver cancer, indicating how changes in methylation patterns could help predict liver cancer risk and mortality.
Article Synopsis
- This study explores how altered DNA methylation (DNAm) may link smoking to lung cancer, using data from the Strong Heart Study (SHS) involving 2,321 participants.
- Researchers found specific differentially methylated positions (DMPs) in blood samples related to lung cancer incidence, with some showing consistent effects in validation from the Framingham Heart Study (FHS).
- The analysis revealed that changes in DNAm at genes AHRR and IER3 could help explain the connection between smoking and lung cancer, prompting the need for further experimental studies to clarify the biological significance of these findings.
Background: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) as potential mediators on the association between arsenic and CVD.
Methods: Blood DNA methylation was measured in 2321 participants (mean age 56.
Importance: American Indian communities experience a high burden of coronary heart disease (CHD). Strategies are needed to identify individuals at risk and implement preventive interventions.
Objective: To investigate the association of blood DNA methylation (DNAm) with incident CHD using a large number of methylation sites (cytosine-phosphate-guanine [CpG]) in a single model.
Background: Epigenetic alterations may contribute to early detection of cancer. We evaluated the association of blood DNA methylation with lymphatic-hematopoietic cancers and, for comparison, with solid cancers. We also evaluated the predictive ability of DNA methylation for lymphatic-hematopoietic cancers.
View Article and Find Full Text PDFBackground: The epigenetic effects of individual environmental toxicants in tobacco remain largely unexplored. Cadmium (Cd) has been associated with smoking-related health effects, and its concentration in tobacco smoke is higher in comparison with other metals.
Objectives: We studied the association of Cd and smoking exposures with human blood DNA methylation (DNAm) profiles.