Publications by authors named "Miguel Castilla-Marti"
Background: Optical coherence tomography (OCT) enables high-resolution imaging of ocular structures in health and disease. Choroid thickness (CT) is a key vascular retinal parameter that can be assessed by OCT and might be relevant in the evaluation of the vascular component of cognitive decline. We aimed to investigate CT changes in a large cohort of individuals cognitive unimpaired (CU), with mild cognitive impairment due to Alzheimer's (MCI-AD), mild cognitive impairment due to cerebrovascular disease (MCI-Va), Alzheimer's disease dementia (ADD), and vascular dementia (VaD).
View Article and Find Full Text PDFIntroduction: Optical coherence tomography angiography (OCT-A) is a novel tool that allows the detection of retinal vascular changes. We investigated the association of macular vessel density (VD) in the superficial plexus assessed by OCT-A with measures of cerebrovascular pathology and atrophy quantified by brain magnetic resonance imaging (MRI) in non-demented individuals.
Methods: Clinical, demographical, OCT-A, and brain MRI data from non-demented research participants were included.
Background: Several studies have reported a relationship between retinal thickness and dementia. Therefore, optical coherence tomography (OCT) has been proposed as an early diagnosis method for Alzheimer's disease (AD). In this study, we performed a genome-wide association study (GWAS) aimed at identifying genes associated with retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) thickness assessed by OCT and exploring the relationships between the spectrum of cognitive decline (including AD and non-AD cases) and retinal thickness.
View Article and Find Full Text PDFBackground: Optical coherence tomography angiography (OCT-A) is a novel method in the dementia field that allows the detection of retinal vascular changes. The comparison of OCT-A measures with established Alzheimer's disease (AD)-related biomarkers is essential to validate the former as a marker of cerebrovascular impairment in the AD continuum. We aimed to investigate the association of macular vessel density (VD) in the superficial plexus quantified by OCT-A with the AT(N) classification based on cerebrospinal fluid (CSF) Aβ1-42, p181-tau and t-tau measurements in individuals with mild cognitive impairment (MCI).
View Article and Find Full Text PDFOptical coherence tomography angiography (OCT-A) allows the detection of retinal vessel density (VD) loss, which is a reflection of brain vascular pathology. We aimed to investigate differences in macular VD in the superficial plexus in a large cohort of individuals cognitively unimpaired (CU), with mild cognitive impairment due to Alzheimer´s disease (MCI-AD), MCI due to cerebrovascular pathology (MCI-Va), probable Alzheimer´s disease dementia (ADD) and Vascular Dementia (VaD). Clinical, demographical, ophthalmological and OCT-A data from the Neuro-ophthalmology Research at Fundació ACE (NORFACE) project were analyzed.
View Article and Find Full Text PDFArticle Synopsis
- Optical coherence tomography (OCT) has been used to measure retinal thickness in patients with subjective cognitive decline (SCD), revealing that these individuals may show retinal layer thinning, which is associated with Alzheimer's disease (AD).
- The study involved 129 SCD participants who underwent OCT and PET scans to examine the link between retinal thickness and amyloid-β accumulation over two years.
- Results indicated that greater thickness in the inner nasal macular region correlates with higher likelihood of amyloid-β positivity, yet no retinal measurements predicted conversion to mild cognitive impairment (MCI) during the study period.
Article Synopsis
- The study aimed to assess whether optical coherence tomography (OCT) can be a reliable biomarker for Alzheimer's disease (AD) and mild cognitive impairment (MCI) by examining macular volume and thickness in 930 participants.
- Despite some previous studies suggesting thinning of the macula in AD and MCI patients, this research found no significant differences in macular thickness or volume across the groups when adjusted for various factors.
- The only notable differences were in specific regions of the inner macular ring, but these were not significant after further statistical adjustments, indicating that OCT may not serve as a valid biomarker for cognitive impairment at this time.
Article Synopsis
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Article Synopsis
- Visual impairment is prevalent among individuals with dementia, and regular eye exams can enhance their quality of life.
- A study involving 1,746 elderly participants found that those with dementia had significantly poorer visual acuity and used fewer visual correction treatments than those with subjective cognitive decline (SCD) or mild cognitive impairment (MCI).
- The quality of optical coherence tomography (OCT) images also declined with cognitive impairment, indicating the need for consistent eye care in dementia patients to address visual issues.
Article Synopsis
- The study aimed to assess the potential of optical coherence tomography (OCT) in measuring retinal nerve fiber layer (RNFL) thickness as a biomarker for Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI).
- Researchers evaluated 930 individuals, finding a non-significant decrease in RNFL thickness across control, MCI, and AD groups, with no significant differences in any measured quadrant.
- The findings suggest that RNFL thickness may not be a reliable marker for cognitive impairment, indicating a need to explore other OCT measurements in different retinal areas as potential biomarkers for AD.
Purpose: To present the outcomes of hybrid multifocal and monofocal intraocular lenses (IOLs) and to compare with refractive and diffractive multifocal IOLs (MFIOLs).
Methods: Three hundred twenty eyes (160 patients) underwent cataract surgery with randomized IOLs bilateral implantation. Changes in uncorrected and distance-corrected logMAR distance, intermediate and near (UNVA and DCNVA) visual acuity (VA), contrast sensitivity (CS), presence of dysphotopsia, spectacle independence, and patient satisfaction were analyzed.
Purpose: To evaluate the effect of vitreous floaters on intraocular straylight.
Methods: Records of bilaterally phakic patients with unilateral complaint of floaters as the main symptom were identified from an electronic database. Patients who underwent straylight measurements on both affected and unaffected eyes using a C-Quant straylight meter were selected.